Cell atlas - TACC3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TACC3
Gene description	Transforming, acidic coiled-coil containing protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated), Cytosol (validated)
Additional location	In addition localized to the Centrosome (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA006050 , CAB010111 , HPA022039
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & endoplasmic reticulum. In addition localized to the centrosome.

Main location

Endoplasmic reticulum (validated), Cytosol (validated)

Additional location

Centrosome (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
CAB010111	A-431	Cytosol
CAB010111	U-2 OS	Endoplasmic reticulum
CAB010111	U-2 OS	Cytosol
CAB010111	U-251 MG	Endoplasmic reticulum
CAB010111	U-251 MG	Cytosol	Intensity
HPA022039	A-431	Centrosome
HPA022039	A-431	Cytosol
HPA022039	U-2 OS	Centrosome
HPA022039	U-2 OS	Cytosol
HPA022039	U-251 MG	Centrosome
HPA022039	U-251 MG	Cytosol
HPA006050	PC-3	Vesicles
HPA006050	PC-3	Cytosol	Intensity
HPA006050	U-2 OS	Endoplasmic reticulum
		Centrosome
		Cytosol	Intensity	Intensity
HPA006050	U-251 MG	Endoplasmic reticulum
		Centrosome
		Cytosol	Intensity

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA006050	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. TACC3 is mostly expressed during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Cytosol

GENE INFORMATION
Gene name	TACC3 (HGNC Symbol)
Synonyms	ERIC1
Description	Transforming, acidic coiled-coil containing protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1721490 - 1745176
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013810 (version 83.38)
Entrez gene	10460
UniProt	Q9Y6A5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6A5
Antibodypedia	TACC3 antibodies

PROTEIN BROWSER

TACC3-001	TACC3-003	TACC3-005	TACC3-006	TACC3-011	TACC3-201	TACC3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TACC3-001 ENSP00000326550 ENST00000313288	Q9Y6A5 [Direct mapping] Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0001666 [response to hypoxia] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0019904 [protein domain specific binding] GO:0021987 [cerebral cortex development] GO:0022008 [neurogenesis] GO:0022027 [interkinetic nuclear migration] GO:0030097 [hemopoiesis] GO:0030953 [astral microtubule organization] GO:0032886 [regulation of microtubule-based process] GO:0042994 [cytoplasmic sequestering of transcription factor] GO:0051726 [regulation of cell cycle] Show all	838 aa 90.4 kDa	No	0
TACC3-003 ENSP00000419210 ENST00000485989	C9JWI7 [Direct mapping] Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	193 aa 21 kDa	No	0
TACC3-005 ENSP00000418095 ENST00000493975	C9JA91 [Direct mapping] Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	231 aa 24.9 kDa	No	0
TACC3-006 ENSP00000420838 ENST00000470136	H0Y8F2 [Direct mapping] Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	217 aa 23.1 kDa	No	0
TACC3-011 ENSP00000415914 ENST00000458173	E7EMT0 [Direct mapping] Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	221 aa 23.8 kDa	No	0
TACC3-201 ENSP00000478580 ENST00000612220	Q8IX09 [Direct mapping] Erythropoietin induced cDNA-1 transcript variant 2; Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	145 aa 15.9 kDa	No	0
TACC3-202 ENSP00000483196 ENST00000617535	Q8IX09 [Direct mapping] Erythropoietin induced cDNA-1 transcript variant 2; Transforming acidic coiled-coil-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0021987 [cerebral cortex development] Show all	145 aa 15.9 kDa	No	0