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TACC3

GENERAL INFORMATION

Gene name

 TACC3

Gene description

 Transforming, acidic coiled-coil containing protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in subsets of cells, most abundant in proliferating cells in lymphoid and hematopoietic tissue, testis and intestinal crypts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA005781 , HPA022039 , CAB010111
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA005781
HPA022039
CAB010111

GENE INFORMATION

Gene name

 TACC3 (HGNC Symbol)

Synonyms

 ERIC1

Description

 Transforming, acidic coiled-coil containing protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1721490 - 1745176

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013810 (version 83.38)

Entrez gene

 10460

UniProt

 Q9Y6A5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6A5

Antibodypedia

 TACC3 antibodies

PROTEIN BROWSER
TACC3-001
TACC3-003
TACC3-005
TACC3-006
TACC3-011
TACC3-201
TACC3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TACC3-001
ENSP00000326550
ENST00000313288
Q9Y6A5 [Direct mapping]
Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001666 [response to hypoxia]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0021987 [cerebral cortex development]
GO:0022008 [neurogenesis]
GO:0022027 [interkinetic nuclear migration]
GO:0030097 [hemopoiesis]
GO:0030953 [astral microtubule organization]
GO:0032886 [regulation of microtubule-based process]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0051726 [regulation of cell cycle]
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 838 aa
90.4 kDa 		No 0
TACC3-003
ENSP00000419210
ENST00000485989
C9JWI7 [Direct mapping]
Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
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 193 aa
21 kDa 		No 0
TACC3-005
ENSP00000418095
ENST00000493975
C9JA91 [Direct mapping]
Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
Show all
 231 aa
24.9 kDa 		No 0
TACC3-006
ENSP00000420838
ENST00000470136
H0Y8F2 [Direct mapping]
Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
Show all
 217 aa
23.1 kDa 		No 0
TACC3-011
ENSP00000415914
ENST00000458173
E7EMT0 [Direct mapping]
Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
Show all
 221 aa
23.8 kDa 		No 0
TACC3-201
ENSP00000478580
ENST00000612220
Q8IX09 [Direct mapping]
Erythropoietin induced cDNA-1 transcript variant 2; Transforming acidic coiled-coil-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
Show all
 145 aa
15.9 kDa 		No 0
TACC3-202
ENSP00000483196
ENST00000617535
Q8IX09 [Direct mapping]
Erythropoietin induced cDNA-1 transcript variant 2; Transforming acidic coiled-coil-containing protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
Show all
 145 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.