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RUFY3

GENERAL INFORMATION

Gene name

 RUFY3

Gene description

 RUN and FYVE domain containing 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, high abundance in CNS and testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA022952 , HPA022970
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), head and neck cancer (favourable) and liver cancer (unfavourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 Pancreatic cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 91011121314151617 Head and neck cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910 Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.05.0101520253035FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022952
HPA022970

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Moderate to strong cytoplasmic positivity was observed in several cases of glioma, renal and liver cancers. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

 RUFY3 (HGNC Symbol)

Synonyms

 KIAA0871, RIPx, Singar1, ZFYVE30

Description

 RUN and FYVE domain containing 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 70704204 - 70807315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000018189 (version 83.38)

Entrez gene

 22902

UniProt

 Q7L099 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L099

Antibodypedia

 RUFY3 antibodies

PROTEIN BROWSER
RUFY3-001
RUFY3-002
RUFY3-003
RUFY3-004
RUFY3-005
RUFY3-007
RUFY3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RUFY3-001
ENSP00000226328
ENST00000226328
Q7L099 [Direct mapping]
Protein RUFY3
A0A024RDD7 [Target identity:100%; Query identity:100%]
RUN and FYVE domain containing 3, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 469 aa
53 kDa 		No 0
RUFY3-002
ENSP00000370394
ENST00000381006
Q7L099 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0046872 [metal ion binding]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 620 aa
70.6 kDa 		No 0
RUFY3-003
ENSP00000425400
ENST00000502653
Q7L099 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0046872 [metal ion binding]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 567 aa
64.7 kDa 		No 0
RUFY3-004
ENSP00000425574
ENST00000513597
D6RCQ1 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 201 aa
22.2 kDa 		No 0
RUFY3-005
ENSP00000399771
ENST00000417478
Q7L099 [Direct mapping]
Protein RUFY3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 506 aa
55.9 kDa 		No 0
RUFY3-007
ENSP00000426734
ENST00000503876
D6REM9 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
17.3 kDa 		No 0
RUFY3-008
ENSP00000426165
ENST00000514898
D6RH24 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 98 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.