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RUFY3

GENERAL INFORMATION

Gene name

 RUFY3

Gene description

 RUN and FYVE domain containing 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, high abundance in CNS and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA022952 , HPA022970
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RUFY3 (HGNC Symbol)

Synonyms

 KIAA0871, RIPx, Singar1, ZFYVE30

Description

 RUN and FYVE domain containing 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 70704204 - 70807315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000018189 (version 83.38)

Entrez gene

 22902

UniProt

 Q7L099 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L099

Antibodypedia

 RUFY3 antibodies

PROTEIN BROWSER
RUFY3-001
RUFY3-002
RUFY3-003
RUFY3-004
RUFY3-005
RUFY3-007
RUFY3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RUFY3-001
ENSP00000226328
ENST00000226328
Q7L099 [Direct mapping]
Protein RUFY3
A0A024RDD7 [Target identity:100%; Query identity:100%]
RUN and FYVE domain containing 3, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 469 aa
53 kDa 		No 0
RUFY3-002
ENSP00000370394
ENST00000381006
Q7L099 [Direct mapping]
Protein RUFY3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0046872 [metal ion binding]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 620 aa
70.6 kDa 		No 0
RUFY3-003
ENSP00000425400
ENST00000502653
Q7L099 [Direct mapping]
Protein RUFY3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0046872 [metal ion binding]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 567 aa
64.7 kDa 		No 0
RUFY3-004
ENSP00000425574
ENST00000513597
D6RCQ1 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 201 aa
22.2 kDa 		No 0
RUFY3-005
ENSP00000399771
ENST00000417478
Q7L099 [Direct mapping]
Protein RUFY3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0043204 [perikaryon]
GO:0045773 [positive regulation of axon extension]
GO:0050771 [negative regulation of axonogenesis]
GO:0071437 [invadopodium]
GO:0090316 [positive regulation of intracellular protein transport]
GO:2000114 [regulation of establishment of cell polarity]
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 506 aa
55.9 kDa 		No 0
RUFY3-007
ENSP00000426734
ENST00000503876
D6REM9 [Direct mapping]
Protein RUFY3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
17.3 kDa 		No 0
RUFY3-008
ENSP00000426165
ENST00000514898
D6RH24 [Direct mapping]
Protein RUFY3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.