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Most cancer types displayed cytoplasmic staining of moderate intensity, while the several cancer tissues were negative. Variations of intensities were observed within the same tumor type.
GENE INFORMATION
Gene name
CD74 (HGNC Symbol)
Synonyms
DHLAG
Description
CD74 molecule, major histocompatibility complex, class II invariant chain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]