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CD74
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CD74

Gene description

CD74 molecule, major histocompatibility complex, class II invariant chain

Protein class

Cancer-related genes
CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in macrophages and immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA010592 , CAB002506
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CD74 (HGNC Symbol)

Synonyms

DHLAG

Description

CD74 molecule, major histocompatibility complex, class II invariant chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

5

Cytoband

q33.1

Chromosome location (bp)

150401637 - 150412929

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000019582 (version 83.38)

Entrez gene

972

UniProt

P04233 (UniProt - Evidence at protein level)

neXtProt

NX_P04233

Antibodypedia

CD74 antibodies

PROTEIN BROWSER

CD74-001
CD74-002
CD74-003
CD74-004
CD74-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD74-001
ENSP00000230685
ENST00000353334
P04233 [Direct mapping]
HLA class II histocompatibility antigen gamma chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [beta-amyloid binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002792 [negative regulation of peptide secretion]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005773 [vacuole]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032588 [trans-Golgi network membrane]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein binding involved in protein folding]
GO:0045058 [T cell selection]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
232 aa
26.4 kDa
No 1
CD74-002
ENSP00000367026
ENST00000377795
P04233 [Direct mapping]
HLA class II histocompatibility antigen gamma chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [beta-amyloid binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002792 [negative regulation of peptide secretion]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005773 [vacuole]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032588 [trans-Golgi network membrane]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein binding involved in protein folding]
GO:0045058 [T cell selection]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
160 aa
18.3 kDa
No 1
CD74-003
ENSP00000009530
ENST00000009530
P04233 [Direct mapping]
HLA class II histocompatibility antigen gamma chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000187 [activation of MAPK activity]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [beta-amyloid binding]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002792 [negative regulation of peptide secretion]
GO:0002830 [positive regulation of type 2 immune response]
GO:0002906 [negative regulation of mature B cell apoptotic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005773 [vacuole]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006886 [intracellular protein transport]
GO:0006952 [defense response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008283 [cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032588 [trans-Golgi network membrane]
GO:0035691 [macrophage migration inhibitory factor signaling pathway]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035693 [NOS2-CD74 complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein binding involved in protein folding]
GO:0045058 [T cell selection]
GO:0045059 [positive thymic T cell selection]
GO:0045060 [negative thymic T cell selection]
GO:0045581 [negative regulation of T cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050998 [nitric-oxide synthase binding]
GO:0051085 [chaperone mediated protein folding requiring cofactor]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
296 aa
33.5 kDa
No 1
CD74-004
ENSP00000430614
ENST00000518797
H0YBZ2 [Direct mapping]
HLA class II histocompatibility antigen gamma chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019882 [antigen processing and presentation]
GO:0042289 [MHC class II protein binding]
Show all
316 aa
35 kDa
No 1
CD74-011
ENSP00000429024
ENST00000524315
E7ESL3 [Direct mapping]
HLA class II histocompatibility antigen gamma chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019882 [antigen processing and presentation]
GO:0042289 [MHC class II protein binding]
Show all
152 aa
17.2 kDa
No 1

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