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VIM

GENERAL INFORMATION

Gene name

 VIM

Gene description

 Vimentin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic and membranous expression in lymphoid tissues, astrocytes, mesenchymal cells, epidermal Langerhans cells and fractions of glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001762 , CAB000080 , CAB058687
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001762
CAB000080
CAB058687

GENE INFORMATION

Gene name

 VIM

Synonyms

Description

 Vimentin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Chromosome

 10

Cytoband

 p13

Chromosome location (bp)

 17228259 - 17237593

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000026025 (version 83.38)

Entrez gene

 7431

UniProt

 P08670 (UniProt - Evidence at protein level)

neXtProt

 NX_P08670

Antibodypedia

 VIM antibodies

PROTEIN BROWSER
VIM-001
VIM-008
VIM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VIM-001
ENSP00000224237
ENST00000224237
P08670 [Direct mapping]
Vimentin
V9HWE1 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 113
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0003725 [double-stranded RNA binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006928 [movement of cell or subcellular component]
GO:0008022 [protein C-terminus binding]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030049 [muscle filament sliding]
GO:0042802 [identical protein binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
GO:1990254 [keratin filament binding]
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 466 aa
53.7 kDa 		No 0
VIM-008
ENSP00000391842
ENST00000421459
Q5JVS8 [Direct mapping]
Vimentin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 173 aa
20 kDa 		No 0
VIM-201
ENSP00000446007
ENST00000544301
P08670 [Direct mapping]
Vimentin
V9HWE1 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 113
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0003725 [double-stranded RNA binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005212 [structural constituent of eye lens]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006928 [movement of cell or subcellular component]
GO:0008022 [protein C-terminus binding]
GO:0010628 [positive regulation of gene expression]
GO:0010977 [negative regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0014002 [astrocyte development]
GO:0016032 [viral process]
GO:0030049 [muscle filament sliding]
GO:0031252 [cell leading edge]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045103 [intermediate filament-based process]
GO:0045109 [intermediate filament organization]
GO:0045111 [intermediate filament cytoskeleton]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060395 [SMAD protein signal transduction]
GO:0070062 [extracellular exosome]
GO:0070307 [lens fiber cell development]
GO:0097110 [scaffold protein binding]
GO:1990254 [keratin filament binding]
Show all
 466 aa
53.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.