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RABEP1

GENERAL INFORMATION

Gene name

 RABEP1

Gene description

 Rabaptin, RAB GTPase binding effector protein 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA019669 , HPA024235 , HPA024691 , CAB004549
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019669
HPA024235
HPA024691
CAB004549

GENE INFORMATION

Gene name

 RABEP1 (HGNC Symbol)

Synonyms

 neurocrescin, RAB5EP, rabaptin-5, RABPT5

Description

 Rabaptin, RAB GTPase binding effector protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 5282265 - 5385812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000029725 (version 83.38)

Entrez gene

 9135

UniProt

 Q15276 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15276

Antibodypedia

 RABEP1 antibodies

PROTEIN BROWSER
RABEP1-001
RABEP1-002
RABEP1-004
RABEP1-005
RABEP1-006
RABEP1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RABEP1-001
ENSP00000445408
ENST00000537505
Q15276 [Direct mapping]
Rab GTPase-binding effector protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0008083 [growth factor activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030139 [endocytic vesicle]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0055037 [recycling endosome]
GO:0061025 [membrane fusion]
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 862 aa
99.3 kDa 		No 0
RABEP1-002
ENSP00000339569
ENST00000341923
Q15276 [Direct mapping]
Rab GTPase-binding effector protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0008083 [growth factor activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030139 [endocytic vesicle]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0055037 [recycling endosome]
GO:0061025 [membrane fusion]
Show all
 829 aa
95.5 kDa 		No 0
RABEP1-004
ENSP00000459550
ENST00000575991
I3L2B8 [Direct mapping]
Rab GTPase-binding effector protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0008083 [growth factor activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 109 aa
12.5 kDa 		No 0
RABEP1-005
ENSP00000482983
ENST00000570487
A0A087WZZ3 [Direct mapping]
Rab GTPase-binding effector protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0008083 [growth factor activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 101 aa
12 kDa 		No 0
RABEP1-006
ENSP00000460980
ENST00000574568
I3L456 [Direct mapping]
Rab GTPase-binding effector protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0008083 [growth factor activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 193 aa
20.6 kDa 		No 0
RABEP1-007
ENSP00000466981
ENST00000572250
K7ENJ9 [Direct mapping]
Rab GTPase-binding effector protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0043547 [positive regulation of GTPase activity]
Show all
 153 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.