Tissue expression of RABEP1 - Summary - The Human Protein Atlas

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RABEP1

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RABEP1
Gene description	Rabaptin, RAB GTPase binding effector protein 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA019669 , HPA024235 , HPA024691 , CAB004549
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RABEP1 (HGNC Symbol)
Synonyms	neurocrescin, RAB5EP, rabaptin-5, RABPT5
Description	Rabaptin, RAB GTPase binding effector protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5282265 - 5385812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000029725 (version 83.38)
Entrez gene	9135
UniProt	Q15276 (UniProt - Evidence at protein level)
neXtProt	NX_Q15276
Antibodypedia	RABEP1 antibodies

PROTEIN BROWSER

RABEP1-001	RABEP1-002	RABEP1-004	RABEP1-005	RABEP1-006	RABEP1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RABEP1-001 ENSP00000445408 ENST00000537505	Q15276 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0006897 [endocytosis] GO:0006915 [apoptotic process] GO:0008083 [growth factor activity] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030139 [endocytic vesicle] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0055037 [recycling endosome] GO:0061025 [membrane fusion] Show all	862 aa 99.3 kDa	No	0
RABEP1-002 ENSP00000339569 ENST00000341923	Q15276 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0006897 [endocytosis] GO:0006915 [apoptotic process] GO:0008083 [growth factor activity] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030139 [endocytic vesicle] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0055037 [recycling endosome] GO:0061025 [membrane fusion] Show all	829 aa 95.5 kDa	No	0
RABEP1-004 ENSP00000459550 ENST00000575991	I3L2B8 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0008083 [growth factor activity] GO:0043547 [positive regulation of GTPase activity] Show all	109 aa 12.5 kDa	No	0
RABEP1-005 ENSP00000482983 ENST00000570487	A0A087WZZ3 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0008083 [growth factor activity] GO:0043547 [positive regulation of GTPase activity] Show all	101 aa 12 kDa	No	0
RABEP1-006 ENSP00000460980 ENST00000574568	I3L456 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0008083 [growth factor activity] GO:0043547 [positive regulation of GTPase activity] Show all	193 aa 20.6 kDa	No	0
RABEP1-007 ENSP00000466981 ENST00000572250	K7ENJ9 [Direct mapping] Rab GTPase-binding effector protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0043547 [positive regulation of GTPase activity] Show all	153 aa 17.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.