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ABCF2

GENERAL INFORMATION

Gene name

 ABCF2

Gene description

 ATP-binding cassette, sub-family F (GCN20), member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Widely distributed cytoplasmic staining.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA020091 , HPA021815 , HPA030388 , CAB020682
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA020091
HPA021815
HPA030388
CAB020682

GENE INFORMATION

Gene name

 ABCF2 (HGNC Symbol)

Synonyms

 ABC28, EST133090, HUSSY-18, M-ABC1

Description

 ATP-binding cassette, sub-family F (GCN20), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Jul 2013]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 151207837 - 151227230

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033050 (version 83.38)

Entrez gene

 10061

UniProt

 Q9UG63 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UG63

Antibodypedia

 ABCF2 antibodies

PROTEIN BROWSER
ABCF2-001
ABCF2-003
ABCF2-004
ABCF2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCF2-001
ENSP00000287844
ENST00000287844
Q9UG63 [Direct mapping]
ATP-binding cassette sub-family F member 2
A0A090N7X1 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family F (GCN20), member 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005740 [mitochondrial envelope]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
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 623 aa
71.3 kDa 		No 0
ABCF2-003
ENSP00000222388
ENST00000222388
Q9UG63 [Direct mapping]
ATP-binding cassette sub-family F member 2
A0A090N7Y2 [Target identity:100%; Query identity:100%]
ATP-binding cassette, sub-family F (GCN20), member 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
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 634 aa
72.4 kDa 		No 0
ABCF2-004
ENSP00000395785
ENST00000441774
C9JHK9 [Direct mapping]
ATP-binding cassette sub-family F member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
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 240 aa
26.9 kDa 		No 0
ABCF2-006
ENSP00000419720
ENST00000468073
C9JZV3 [Direct mapping]
ATP-binding cassette sub-family F member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 288 aa
32.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.