Most malignant cells showed weak to moderate immunoreactivity. A few cases of strong positivity was observed in malignant melanoma, colorectal, urothelial and testicular cancers. Several cases of malignant gliomas, renal and liver cancers were negative.
Most malignancies were weakly stained or negative. Moderate cytoplasmic staining was observed in several malignant lymphomas and melanomas.
ABCF2 (HGNC Symbol)
ABC28, EST133090, HUSSY-18, M-ABC1
ATP-binding cassette, sub-family F (GCN20), member 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Jul 2013]