Cell atlas - C6 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

C6

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	C6
Gene description	Complement component 6
Protein class	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	C6
Synonyms
Description	Complement component 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	41142234 - 41261438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000039537 (version 83.38)
Entrez gene	729
UniProt	P13671 (UniProt - Evidence at protein level)
neXtProt	NX_P13671
Antibodypedia	C6 antibodies

PROTEIN BROWSER

C6-001	C6-002	C6-003	C6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C6-001 ENSP00000263413 ENST00000263413	P13671 [Direct mapping] Complement component C6 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001970 [positive regulation of activation of membrane attack complex] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0045766 [positive regulation of angiogenesis] GO:0045917 [positive regulation of complement activation] GO:0070062 [extracellular exosome] Show all	934 aa 104.8 kDa	Yes	0
C6-002 ENSP00000338861 ENST00000337836	P13671 [Direct mapping] Complement component C6 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	934 aa 104.8 kDa	Yes	0
C6-003 ENSP00000401578 ENST00000433294	C9JX36 [Direct mapping] Complement component C6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.6 kDa	Yes	0
C6-004 ENSP00000396565 ENST00000417809	C9JC72 [Direct mapping] Complement component C6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		133 aa 15.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.