Tissue expression of C6 - Summary - The Human Protein Atlas

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C6

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	C6
Gene description	Complement component 6
Protein class	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (fallopian tube, liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct staining in plasma and extracellular compartments.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA043823 , CAB069427
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (fallopian tube, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	C6
Synonyms
Description	Complement component 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	41142234 - 41261438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000039537 (version 83.38)
Entrez gene	729
UniProt	P13671 (UniProt - Evidence at protein level)
neXtProt	NX_P13671
Antibodypedia	C6 antibodies

PROTEIN BROWSER

C6-001	C6-002	C6-003	C6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C6-001 ENSP00000263413 ENST00000263413	P13671 [Direct mapping] Complement component C6 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001970 [positive regulation of activation of membrane attack complex] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0045766 [positive regulation of angiogenesis] GO:0045917 [positive regulation of complement activation] GO:0070062 [extracellular exosome] Show all	934 aa 104.8 kDa	Yes	0
C6-002 ENSP00000338861 ENST00000337836	P13671 [Direct mapping] Complement component C6 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	934 aa 104.8 kDa	Yes	0
C6-003 ENSP00000401578 ENST00000433294	C9JX36 [Direct mapping] Complement component C6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.6 kDa	Yes	0
C6-004 ENSP00000396565 ENST00000417809	C9JC72 [Direct mapping] Complement component C6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		133 aa 15.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.