Expression of TG in cancer - Summary - The Human Protein Atlas

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TG

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TG
Gene description	Thyroglobulin
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (HDLM-2, Karpas-707, PC-3)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA002740 , CAB000077 , CAB056155
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002740	CAB000077	CAB056155

GENE INFORMATION
Gene name	TG (HGNC Symbol)
Synonyms	AITD3, TGN
Description	Thyroglobulin (HGNC Symbol)
Entrez gene summary	Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Chromosome	8
Cytoband	q24.22
Chromosome location (bp)	132866958 - 133134903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000042832 (version 83.38)
Entrez gene	7038
UniProt	P01266 (UniProt - Evidence at protein level)
neXtProt	NX_P01266
Antibodypedia	TG antibodies

PROTEIN BROWSER

TG-001	TG-003	TG-004	TG-005	TG-007	TG-010	TG-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TG-001 ENSP00000220616 ENST00000220616	P01266 [Direct mapping] Thyroglobulin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0007165 [signal transduction] GO:0009268 [response to pH] GO:0015705 [iodide transport] GO:0030878 [thyroid gland development] GO:0031641 [regulation of myelination] GO:0032403 [protein complex binding] GO:0032496 [response to lipopolysaccharide] GO:0042403 [thyroid hormone metabolic process] GO:0042446 [hormone biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0043168 [anion binding] GO:0043234 [protein complex] GO:0045056 [transcytosis] GO:0048471 [perinuclear region of cytoplasm] GO:0051087 [chaperone binding] Show all	2768 aa 304.8 kDa	Yes	0
TG-003 ENSP00000430523 ENST00000519178	H0YBY1 [Direct mapping] Thyroglobulin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1224 aa 134.6 kDa	No	0
TG-004 ENSP00000429164 ENST00000518058	H0YBC5 [Direct mapping] Thyroglobulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.6 kDa	No	0
TG-005 ENSP00000430430 ENST00000519543	E7EVM0 [Direct mapping] Thyroglobulin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		901 aa 99.4 kDa	No	0
TG-007 ENSP00000430161 ENST00000521107	H0YBR7 [Direct mapping] Thyroglobulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.3 kDa	No	0
TG-010 ENSP00000429761 ENST00000518108	H0YBL4 [Direct mapping] Thyroglobulin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		194 aa 20.9 kDa	No	0
TG-017 ENSP00000429605 ENST00000518505	H0YBJ2 [Direct mapping] Thyroglobulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 23.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.