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TG

GENERAL INFORMATION

Gene name

 TG

Gene description

 Thyroglobulin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (thyroid gland)
GTEx:Tissue enriched (thyroid gland)
FANTOM5:Tissue enriched (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in thyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA002740 , CAB000077 , CAB056155
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)

GENE INFORMATION

Gene name

 TG (HGNC Symbol)

Synonyms

 AITD3, TGN

Description

 Thyroglobulin (HGNC Symbol)

Entrez gene summary

 Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Chromosome

 8

Cytoband

 q24.22

Chromosome location (bp)

 132866958 - 133134903

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042832 (version 83.38)

Entrez gene

 7038

UniProt

 P01266 (UniProt - Evidence at protein level)

neXtProt

 NX_P01266

Antibodypedia

 TG antibodies

PROTEIN BROWSER
TG-001
TG-003
TG-004
TG-005
TG-007
TG-010
TG-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TG-001
ENSP00000220616
ENST00000220616
P01266 [Direct mapping]
Thyroglobulin
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007165 [signal transduction]
GO:0009268 [response to pH]
GO:0015705 [iodide transport]
GO:0030878 [thyroid gland development]
GO:0031641 [regulation of myelination]
GO:0032403 [protein complex binding]
GO:0032496 [response to lipopolysaccharide]
GO:0042403 [thyroid hormone metabolic process]
GO:0042446 [hormone biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043168 [anion binding]
GO:0043234 [protein complex]
GO:0045056 [transcytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
Show all
 2768 aa
304.8 kDa 		Yes 0
TG-003
ENSP00000430523
ENST00000519178
H0YBY1 [Direct mapping]
Thyroglobulin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1224 aa
134.6 kDa 		No 0
TG-004
ENSP00000429164
ENST00000518058
H0YBC5 [Direct mapping]
Thyroglobulin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
6.6 kDa 		No 0
TG-005
ENSP00000430430
ENST00000519543
E7EVM0 [Direct mapping]
Thyroglobulin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 901 aa
99.4 kDa 		No 0
TG-007
ENSP00000430161
ENST00000521107
H0YBR7 [Direct mapping]
Thyroglobulin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
19.3 kDa 		No 0
TG-010
ENSP00000429761
ENST00000518108
H0YBL4 [Direct mapping]
Thyroglobulin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 194 aa
20.9 kDa 		No 0
TG-017
ENSP00000429605
ENST00000518505
H0YBJ2 [Direct mapping]
Thyroglobulin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 226 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.