Expression of WDR37 in cancer - Summary - The Human Protein Atlas

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WDR37

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WDR37
Gene description	WD repeat domain 37
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA037376 , HPA037565
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), thyroid cancer (unfavourable) and head and neck cancer (favourable).
Pancreatic cancer p<0.001 Thyroid cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037376	HPA037565

GENE INFORMATION
Gene name	WDR37 (HGNC Symbol)
Synonyms	KIAA0982
Description	WD repeat domain 37 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p15.3
Chromosome location (bp)	1049538 - 1132297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047056 (version 83.38)
Entrez gene	22884
UniProt	Q9Y2I8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2I8
Antibodypedia	WDR37 antibodies

PROTEIN BROWSER

WDR37-001	WDR37-002	WDR37-004	WDR37-005	WDR37-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR37-001 ENSP00000350954 ENST00000358220	Q9Y2I8 [Direct mapping] WD repeat-containing protein 37 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	494 aa 54.7 kDa	No	0
WDR37-002 ENSP00000263150 ENST00000263150	Q9Y2I8 [Direct mapping] WD repeat-containing protein 37 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	494 aa 54.7 kDa	No	0
WDR37-004 ENSP00000370730 ENST00000381329	E7EQ49 [Direct mapping] WD repeat-containing protein 37 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	249 aa 27.4 kDa	No	0
WDR37-005 ENSP00000404346 ENST00000436154	C9JGR9 [Direct mapping] WD repeat-containing protein 37 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	209 aa 22.9 kDa	No	0
WDR37-201 ENSP00000478057 ENST00000620998	A0A087WTQ2 [Direct mapping] WD repeat-containing protein 37 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	263 aa 29.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.