Cell atlas - CELF2 - The Human Protein Atlas

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CELF2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Microtubules
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CELF2
Gene description	CUGBP, Elav-like family member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules & cytokinetic bridge. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEL, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (uncertain), Cytokinetic bridge (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA035813 , HPA065098
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules & cytokinetic bridge. In addition localized to the nucleoplasm.

Main location

Microtubules (uncertain), Cytokinetic bridge (uncertain)

Additional location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA035813	HEK 293	Nucleoplasm
HPA035813	HEK 293	Vesicles
HPA035813	RH-30	Nucleoplasm
HPA035813	U-2 OS	Nucleoplasm
HPA035813	U-2 OS	Cytokinetic bridge	Intensity	Intensity
HPA065098	RH-30	Microtubules
HPA065098	SK-MEL-30	Microtubules
HPA065098	U-2 OS	Microtubules

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	CELF2 (HGNC Symbol)
Synonyms	BRUNOL3, CUGBP2, Etr-3, NAPOR-2
Description	CUGBP, Elav-like family member 2 (HGNC Symbol)
Entrez gene summary	Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	11005321 - 11336675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000048740 (version 83.38)
Entrez gene	10659
UniProt	O95319 (UniProt - Evidence at protein level)
neXtProt	NX_O95319
Antibodypedia	CELF2 antibodies

PROTEIN BROWSER

CELF2-001	CELF2-002	CELF2-003	CELF2-004	CELF2-005	CELF2-007	CELF2-008	CELF2-010	CELF2-011	CELF2-012	CELF2-015	CELF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELF2-001 ENSP00000404834 ENST00000417956	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	490 aa 52.3 kDa	No	0
CELF2-002 ENSP00000382743 ENST00000399850	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	490 aa 52.3 kDa	No	0
CELF2-003 ENSP00000346971 ENST00000354897	Q5VZZ6 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	502 aa 53.7 kDa	No	0
CELF2-004 ENSP00000476999 ENST00000608830	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	488 aa 52.1 kDa	No	0
CELF2-005 ENSP00000476656 ENST00000609692	V9GYD9 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	440 aa 46.6 kDa	No	0
CELF2-007 ENSP00000406451 ENST00000416382	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	508 aa 54.3 kDa	No	0
CELF2-008 ENSP00000488582 ENST00000631460	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	508 aa 54.3 kDa	No	0
CELF2-010 ENSP00000488268 ENST00000631816		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	514 aa 54.9 kDa	No	0
CELF2-011 ENSP00000488422 ENST00000632065		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	533 aa 57.1 kDa	No	0
CELF2-012 ENSP00000488690 ENST00000633077		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	521 aa 55.7 kDa	No	0
CELF2-015 ENSP00000487802 ENST00000632728	O95319 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008016 [regulation of heart contraction] GO:0044822 [poly(A) RNA binding] Show all	490 aa 52.3 kDa	No	0
CELF2-201 ENSP00000443926 ENST00000542579	E9PC62 [Direct mapping] CUGBP Elav-like family member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0006376 [mRNA splice site selection] Show all	521 aa 55.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.