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VAMP3

GENERAL INFORMATION

Gene name

 VAMP3

Gene description

 Vesicle-associated membrane protein 3

Protein class

 Cancer-related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VAMP3 (HGNC Symbol)

Synonyms

 CEB

Description

 Vesicle-associated membrane protein 3 (HGNC Symbol)

Entrez gene summary

 Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.23

Chromosome location (bp)

 7771269 - 7781432

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000049245 (version 83.38)

Entrez gene

 9341

UniProt

 Q15836 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15836

Antibodypedia

 VAMP3 antibodies

PROTEIN BROWSER
VAMP3-001
VAMP3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VAMP3-001
ENSP00000054666
ENST00000054666
Q15836 [Direct mapping]
Vesicle-associated membrane protein 3
Q6FGG2 [Target identity:100%; Query identity:100%]
VAMP3 protein; Vesicle-associated membrane protein 3 (Cellubrevin); cDNA, FLJ92013, Homo sapiens vesicle-associated membrane protein 3 (cellubrevin)(VAMP3), mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0001921 [positive regulation of receptor recycling]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006887 [exocytosis]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016324 [apical plasma membrane]
GO:0017075 [syntaxin-1 binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0030054 [cell junction]
GO:0030136 [clathrin-coated vesicle]
GO:0030141 [secretory granule]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035493 [SNARE complex assembly]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043005 [neuron projection]
GO:0043229 [intracellular organelle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055037 [recycling endosome]
GO:0061025 [membrane fusion]
GO:1903531 [negative regulation of secretion by cell]
Show all
 100 aa
11.3 kDa 		No 1
VAMP3-002
ENSP00000465820
ENST00000470357
K7EKX0 [Direct mapping]
Vesicle-associated membrane protein 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 72 aa
8.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.