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PUM2

GENERAL INFORMATION

Gene name

 PUM2

Gene description

 Pumilio RNA-binding family member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic staining, often with a granular staining, in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030316
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030316

GENE INFORMATION

Gene name

 PUM2 (HGNC Symbol)

Synonyms

 KIAA0235, PUMH2

Description

 Pumilio RNA-binding family member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 2

Cytoband

 p24.1

Chromosome location (bp)

 20248691 - 20352234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055917 (version 83.38)

Entrez gene

 23369

UniProt

 Q8TB72 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TB72

Antibodypedia

 PUM2 antibodies

PROTEIN BROWSER
PUM2-001
PUM2-002
PUM2-003
PUM2-006
PUM2-009
PUM2-201
PUM2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PUM2-001
ENSP00000338173
ENST00000338086
Q8TB72 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0010494 [cytoplasmic stress granule]
GO:0031965 [nuclear membrane]
GO:0034063 [stress granule assembly]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060964 [regulation of gene silencing by miRNA]
GO:1900246 [positive regulation of RIG-I signaling pathway]
GO:2000637 [positive regulation of gene silencing by miRNA]
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 1064 aa
114 kDa 		No 0
PUM2-002
ENSP00000385992
ENST00000403432
Q8TB72 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0010494 [cytoplasmic stress granule]
GO:0031965 [nuclear membrane]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060964 [regulation of gene silencing by miRNA]
GO:1900246 [positive regulation of RIG-I signaling pathway]
GO:2000637 [positive regulation of gene silencing by miRNA]
Show all
 1064 aa
114 kDa 		No 0
PUM2-003
ENSP00000409905
ENST00000440577
A0A0C4DG68 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005488 [binding]
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 876 aa
94.1 kDa 		No 0
PUM2-006
ENSP00000387399
ENST00000442400
C9JW01 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
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 293 aa
32 kDa 		No 0
PUM2-009
ENSP00000395098
ENST00000424110
C9JE24 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 34 aa
3.9 kDa 		No 0
PUM2-201
ENSP00000326746
ENST00000319801
A0A0A0MR59 [Direct mapping]
Pumilio homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005488 [binding]
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 929 aa
99.6 kDa 		No 0
PUM2-202
ENSP00000354370
ENST00000361078
Q8TB72 [Direct mapping]
Pumilio homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0010494 [cytoplasmic stress granule]
GO:0031965 [nuclear membrane]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060964 [regulation of gene silencing by miRNA]
GO:1900246 [positive regulation of RIG-I signaling pathway]
GO:2000637 [positive regulation of gene silencing by miRNA]
Show all
 1008 aa
107.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.