Cell atlas - GYG2 - The Human Protein Atlas

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GYG2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GYG2
Gene description	Glycogenin 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus, nucleoli & cytosol.
RNA cell category	Cell line enhanced (SK-MEL-30, NTERA-2, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064686
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, NTERA-2, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus, nucleoli & cytosol.

Main location

Nucleus (approved), Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064686	CACO-2	Nucleoli	Intensity
	HPA064686	CACO-2	Cytosol	Intensity
	HPA064686	SK-MEL-30	Nucleus	Intensity
			Nucleoli	Intensity
			Cytosol	Intensity
	HPA064686	U-2 OS	Nucleus
			Nucleoli	Intensity
			Cytosol	Intensity

GENE INFORMATION
Gene name	GYG2 (HGNC Symbol)
Synonyms	GN-2
Description	Glycogenin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	2828788 - 2882818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000056998 (version 83.38)
Entrez gene	8908
UniProt	O15488 (UniProt - Evidence at protein level)
neXtProt	NX_O15488
Antibodypedia	GYG2 antibodies

PROTEIN BROWSER

GYG2-001	GYG2-005	GYG2-007	GYG2-008	GYG2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYG2-001 ENSP00000370555 ENST00000381163	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	501 aa 55.2 kDa	No	0
GYG2-005 ENSP00000487294 ENST00000353656	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	430 aa 47.5 kDa	No	0
GYG2-007 ENSP00000381786 ENST00000398806	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	470 aa 52 kDa	No	0
GYG2-008 ENSP00000430764 ENST00000520904	E5RIC9 [Direct mapping] Glycogenin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	138 aa 15.5 kDa	No	0
GYG2-010 ENSP00000370549 ENST00000381157	J3QSZ3 [Direct mapping] Glycogenin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	244 aa 26.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.