Expression of GYG2 in cancer - Summary - The Human Protein Atlas

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GYG2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GYG2
Gene description	Glycogenin 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, NTERA-2, SK-MEL-30)
HPA (normal tissue):	Tissue enriched (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression most abundant in liver and adipocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA005495 , HPA064686
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005495	HPA064686

GENE INFORMATION
Gene name	GYG2 (HGNC Symbol)
Synonyms	GN-2
Description	Glycogenin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	2828788 - 2882818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000056998 (version 83.38)
Entrez gene	8908
UniProt	O15488 (UniProt - Evidence at protein level)
neXtProt	NX_O15488
Antibodypedia	GYG2 antibodies

PROTEIN BROWSER

GYG2-001	GYG2-005	GYG2-007	GYG2-008	GYG2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYG2-001 ENSP00000370555 ENST00000381163	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	501 aa 55.2 kDa	No	0
GYG2-005 ENSP00000487294 ENST00000353656	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	430 aa 47.5 kDa	No	0
GYG2-007 ENSP00000381786 ENST00000398806	O15488 [Direct mapping] Glycogenin-2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008466 [glycogenin glucosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] Show all	470 aa 52 kDa	No	0
GYG2-008 ENSP00000430764 ENST00000520904	E5RIC9 [Direct mapping] Glycogenin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	138 aa 15.5 kDa	No	0
GYG2-010 ENSP00000370549 ENST00000381157	J3QSZ3 [Direct mapping] Glycogenin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	244 aa 26.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.