Cell atlas - SFSWAP - The Human Protein Atlas

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SFSWAP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SFSWAP
Gene description	Splicing factor, suppressor of white-apricot family
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA039362 , HPA040063
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the plasma membrane & cytosol.

Main location

Nucleus (approved)

Additional location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039362	A-431	Nucleus
HPA039362	A-431	Plasma membrane
HPA039362	U-2 OS	Nucleus
HPA039362	U-2 OS	Plasma membrane
HPA039362	U-251 MG	Nucleus
HPA039362	U-251 MG	Plasma membrane
HPA040063	A-431	Nucleoplasm
HPA040063	A-431	Cytosol
HPA040063	U-2 OS	Nucleus
HPA040063	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SFSWAP (HGNC Symbol)
Synonyms	SFRS8, SWAP
Description	Splicing factor, suppressor of white-apricot family (HGNC Symbol)
Entrez gene summary	This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Chromosome	12
Cytoband	q24.33
Chromosome location (bp)	131711081 - 131799737
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000061936 (version 83.38)
Entrez gene	6433
UniProt	Q12872 (UniProt - Evidence at protein level)
neXtProt	NX_Q12872
Antibodypedia	SFSWAP antibodies

PROTEIN BROWSER

SFSWAP-001	SFSWAP-003	SFSWAP-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFSWAP-001 ENSP00000261674 ENST00000261674	Q12872 [Direct mapping] Splicing factor, suppressor of white-apricot homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] Show all	951 aa 104.8 kDa	No	0
SFSWAP-003 ENSP00000437738 ENST00000541286	Q12872 [Direct mapping] Splicing factor, suppressor of white-apricot homolog Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000395 [mRNA 5'-splice site recognition] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] Show all	1003 aa 110 kDa	No	0
SFSWAP-008 ENSP00000439957 ENST00000537164	H0YFR9 [Direct mapping] Splicing factor, suppressor of white-apricot homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0006396 [RNA processing] Show all	320 aa 34.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.