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SFSWAP

GENERAL INFORMATION

Gene name

 SFSWAP

Gene description

 Splicing factor, suppressor of white-apricot family

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039362 , HPA040063
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039362
HPA040063

GENE INFORMATION

Gene name

 SFSWAP (HGNC Symbol)

Synonyms

 SFRS8, SWAP

Description

 Splicing factor, suppressor of white-apricot family (HGNC Symbol)

Entrez gene summary

 This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 131711081 - 131799737

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000061936 (version 83.38)

Entrez gene

 6433

UniProt

 Q12872 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12872

Antibodypedia

 SFSWAP antibodies

PROTEIN BROWSER
SFSWAP-001
SFSWAP-003
SFSWAP-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SFSWAP-001
ENSP00000261674
ENST00000261674
Q12872 [Direct mapping]
Splicing factor, suppressor of white-apricot homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
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 951 aa
104.8 kDa 		No 0
SFSWAP-003
ENSP00000437738
ENST00000541286
Q12872 [Direct mapping]
Splicing factor, suppressor of white-apricot homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000395 [mRNA 5'-splice site recognition]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
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 1003 aa
110 kDa 		No 0
SFSWAP-008
ENSP00000439957
ENST00000537164
H0YFR9 [Direct mapping]
Splicing factor, suppressor of white-apricot homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0006396 [RNA processing]
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 320 aa
34.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.