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MTMR1

GENERAL INFORMATION

Gene name

 MTMR1

Gene description

 Myotubularin related protein 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA018502
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MTMR1

Synonyms

Description

 Myotubularin related protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 150692971 - 150765103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000063601 (version 83.38)

Entrez gene

 8776

UniProt

 Q13613 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13613

Antibodypedia

 MTMR1 antibodies

PROTEIN BROWSER
MTMR1-002
MTMR1-005
MTMR1-006
MTMR1-007
MTMR1-008
MTMR1-009
MTMR1-010
MTMR1-012
MTMR1-013
MTMR1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTMR1-002
ENSP00000414178
ENST00000445323
F8WA39 [Direct mapping]
Myotubularin-related protein 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 673 aa
75.7 kDa 		No 0
MTMR1-005
ENSP00000390736
ENST00000429965
F8W764 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 87 aa
9.6 kDa 		No 0
MTMR1-006
ENSP00000389884
ENST00000438018
H7BZJ1 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 132 aa
14.8 kDa 		No 0
MTMR1-007
ENSP00000414925
ENST00000436701
H7C406 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 149 aa
16.8 kDa 		No 0
MTMR1-008
ENSP00000436957
ENST00000490316
E9PPP8 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 185 aa
19.5 kDa 		No 0
MTMR1-009
ENSP00000404599
ENST00000439546
F8W8S8 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 90 aa
10 kDa 		No 0
MTMR1-010
ENSP00000405946
ENST00000434699
F8W764 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 87 aa
9.6 kDa 		No 0
MTMR1-012
ENSP00000431992
ENST00000493995
E9PIH9 [Direct mapping]
Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 147 aa
16.7 kDa 		No 0
MTMR1-013
ENSP00000359417
ENST00000370390
Q13613 [Direct mapping]
Myotubularin-related protein 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 665 aa
74.7 kDa 		No 0
MTMR1-201
ENSP00000445281
ENST00000542156
Q8NEC6 [Direct mapping]
MTMR1 protein; Myotubularin related protein 1, isoform CRA_b; Myotubularin-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004438 [phosphatidylinositol-3-phosphatase activity]
GO:0046856 [phosphatidylinositol dephosphorylation]
GO:0052629 [phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity]
Show all
 363 aa
39.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.