Expression of ROPN1 in cancer - Summary - The Human Protein Atlas

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ROPN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ROPN1
Gene description	Rhophilin associated tail protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA052530 , CAB014875
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052530	CAB014875

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancers exhibited moderate to strong cytoplasmic positivity. Lymphomas, gliomas and prostate cancers along with several melanomas, skin, breast and testicular cancers were weakly stained or negative.

GENE INFORMATION
Gene name	ROPN1 (HGNC Symbol)
Synonyms	CT91, ODF6, ROPN1A, ropporin
Description	Rhophilin associated tail protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	123968521 - 123992178
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065371 (version 83.38)
Entrez gene	54763
UniProt	Q9HAT0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAT0
Antibodypedia	ROPN1 antibodies

PROTEIN BROWSER

ROPN1-001	ROPN1-002	ROPN1-003	ROPN1-004	ROPN1-005	ROPN1-008	ROPN1-009	ROPN1-010	ROPN1-013	ROPN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROPN1-001 ENSP00000184183 ENST00000184183	Q9HAT0 [Direct mapping] Ropporin-1A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	212 aa 23.9 kDa	No	0
ROPN1-002 ENSP00000420567 ENST00000479867	Q9HAT0 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	58 aa 6.7 kDa	No	0
ROPN1-003 ENSP00000417379 ENST00000495093	Q9HAT0 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	58 aa 6.7 kDa	No	0
ROPN1-004 ENSP00000420590 ENST00000459660	Q9HAT0 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	58 aa 6.7 kDa	No	0
ROPN1-005 ENSP00000385919 ENST00000405845	Q9HAT0 [Direct mapping] Ropporin-1A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	212 aa 23.9 kDa	No	0
ROPN1-008 ENSP00000418931 ENST00000496145	C9J012 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all		77 aa 8.8 kDa	No	0
ROPN1-009 ENSP00000420310 ENST00000460743	C9JP07 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all		116 aa 13.2 kDa	No	0
ROPN1-010 ENSP00000419205 ENST00000484329	Q9HAT0 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	58 aa 6.7 kDa	No	0
ROPN1-013 ENSP00000417067 ENST00000467907	C9J6H4 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all		130 aa 14.8 kDa	No	0
ROPN1-201 ENSP00000483603 ENST00000620893	Q9HAT0 [Direct mapping] Ropporin-1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007264 [small GTPase mediated signal transduction] Show all	212 aa 23.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.