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PDE4A

GENERAL INFORMATION

Gene name

 PDE4A

Gene description

 Phosphodiesterase 4A, cAMP-specific

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA043310 , CAB017632
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043310
CAB017632

GENE INFORMATION

Gene name

 PDE4A (HGNC Symbol)

Synonyms

 DPDE2

Description

 Phosphodiesterase 4A, cAMP-specific (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10416773 - 10469631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065989 (version 83.38)

Entrez gene

 5141

UniProt

 P27815 (UniProt - Evidence at protein level)

neXtProt

 NX_P27815

Antibodypedia

 PDE4A antibodies

PROTEIN BROWSER
PDE4A-001
PDE4A-002
PDE4A-003
PDE4A-004
PDE4A-005
PDE4A-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE4A-001
ENSP00000370078
ENST00000380702
P27815 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0007608 [sensory perception of smell]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010738 [regulation of protein kinase A signaling]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0032587 [ruffle membrane]
GO:0035690 [cellular response to drug]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 886 aa
98.1 kDa 		No 0
PDE4A-002
ENSP00000293683
ENST00000293683
P27815 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0032587 [ruffle membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 860 aa
95.2 kDa 		No 0
PDE4A-003
ENSP00000394754
ENST00000440014
P27815 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0032587 [ruffle membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 825 aa
91.3 kDa 		No 0
PDE4A-004
ENSP00000341007
ENST00000344979
P27815 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0032587 [ruffle membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 647 aa
72.2 kDa 		No 0
PDE4A-005
ENSP00000468507
ENST00000592685
P27815 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0032587 [ruffle membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 864 aa
95.6 kDa 		No 0
PDE4A-008
ENSP00000467137
ENST00000591971
K7ENX7 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
Show all
 279 aa
32 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.