Tissue expression of PDE4A - Summary - The Human Protein Atlas

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PDE4A

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PDE4A
Gene description	Phosphodiesterase 4A, cAMP-specific
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA043310 , CAB017632
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PDE4A (HGNC Symbol)
Synonyms	DPDE2
Description	Phosphodiesterase 4A, cAMP-specific (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10416773 - 10469631
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065989 (version 83.38)
Entrez gene	5141
UniProt	P27815 (UniProt - Evidence at protein level)
neXtProt	NX_P27815
Antibodypedia	PDE4A antibodies

PROTEIN BROWSER

PDE4A-001	PDE4A-002	PDE4A-003	PDE4A-004	PDE4A-005	PDE4A-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE4A-001 ENSP00000370078 ENST00000380702	P27815 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0007608 [sensory perception of smell] GO:0008081 [phosphoric diester hydrolase activity] GO:0010738 [regulation of protein kinase A signaling] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0032587 [ruffle membrane] GO:0035690 [cellular response to drug] GO:0043949 [regulation of cAMP-mediated signaling] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	886 aa 98.1 kDa	No	0
PDE4A-002 ENSP00000293683 ENST00000293683	P27815 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0032587 [ruffle membrane] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	860 aa 95.2 kDa	No	0
PDE4A-003 ENSP00000394754 ENST00000440014	P27815 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0032587 [ruffle membrane] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	825 aa 91.3 kDa	No	0
PDE4A-004 ENSP00000341007 ENST00000344979	P27815 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0032587 [ruffle membrane] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	647 aa 72.2 kDa	No	0
PDE4A-005 ENSP00000468507 ENST00000592685	P27815 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0032587 [ruffle membrane] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	864 aa 95.6 kDa	No	0
PDE4A-008 ENSP00000467137 ENST00000591971	K7ENX7 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4A Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] Show all	279 aa 32 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.