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ZNRD1

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GENERAL INFORMATION

Gene name

 ZNRD1

Gene description

 Zinc ribbon domain containing 1

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli (fibrillar center).

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (supported)

Mouse

 Localized to the Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA055074
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055074 A-431 Nucleoli fibrillar center
HPA055074 PC-3 Nucleoli fibrillar center
HPA055074 U-2 OS Nucleoli fibrillar center

MOUSE CELLS

Main location

 Cytosol

Additional location

 Nuclear bodies

Mouse gene

 ENSMUSG00000036315 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA055074 NIH 3T3 Nuclear bodies
Cytosol

GENE INFORMATION

Gene name

 ZNRD1 (HGNC Symbol)

Synonyms

 HTEX-6, hZR14, RPA12, tctex-6

Description

 Zinc ribbon domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 30058899 - 30064909

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066379 (version 83.38)

Entrez gene

 30834

UniProt

 Q9P1U0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9P1U0

Antibodypedia

 ZNRD1 antibodies

PROTEIN BROWSER
ZNRD1-001
ZNRD1-002
ZNRD1-005
ZNRD1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNRD1-001
ENSP00000352333
ENST00000359374
Q9P1U0 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA12
Q2L6J2 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003676 [nucleic acid binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 126 aa
13.9 kDa 		No 0
ZNRD1-002
ENSP00000331111
ENST00000332435
Q9P1U0 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA12
Q2L6J2 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003676 [nucleic acid binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 126 aa
13.9 kDa 		No 0
ZNRD1-005
ENSP00000365978
ENST00000376782
Q9P1U0 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA12
Q2L6J2 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003676 [nucleic acid binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 126 aa
13.9 kDa 		No 0
ZNRD1-006
ENSP00000365981
ENST00000376785
Q9P1U0 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA12
Q2L6J2 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003676 [nucleic acid binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 126 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.