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This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Q8IXJ6 [Direct mapping] NAD-dependent protein deacetylase sirtuin-2
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000183 [chromatin silencing at rDNA] GO:0003682 [chromatin binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005677 [chromatin silencing complex] GO:0005694 [chromosome] GO:0005720 [nuclear heterochromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0006342 [chromatin silencing] GO:0006348 [chromatin silencing at telomere] GO:0006351 [transcription, DNA-templated] GO:0006471 [protein ADP-ribosylation] GO:0006476 [protein deacetylation] GO:0006914 [autophagy] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0007417 [central nervous system development] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010507 [negative regulation of autophagy] GO:0010801 [negative regulation of peptidyl-threonine phosphorylation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016458 [gene silencing] GO:0016575 [histone deacetylation] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017136 [NAD-dependent histone deacetylase activity] GO:0021762 [substantia nigra development] GO:0022011 [myelination in peripheral nervous system] GO:0030426 [growth cone] GO:0030496 [midbody] GO:0031641 [regulation of myelination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0033010 [paranodal junction] GO:0033270 [paranode region of axon] GO:0033558 [protein deacetylase activity] GO:0034599 [cellular response to oxidative stress] GO:0034979 [NAD-dependent protein deacetylase activity] GO:0034983 [peptidyl-lysine deacetylation] GO:0035035 [histone acetyltransferase binding] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0035748 [myelin sheath abaxonal region] GO:0042177 [negative regulation of protein catabolic process] GO:0042325 [regulation of phosphorylation] GO:0042826 [histone deacetylase binding] GO:0042903 [tubulin deacetylase activity] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043204 [perikaryon] GO:0043209 [myelin sheath] GO:0043219 [lateral loop] GO:0043220 [Schmidt-Lanterman incisure] GO:0043388 [positive regulation of DNA binding] GO:0043491 [protein kinase B signaling] GO:0044224 [juxtaparanode region of axon] GO:0044242 [cellular lipid catabolic process] GO:0045087 [innate immune response] GO:0045598 [regulation of fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045836 [positive regulation of meiotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048487 [beta-tubulin binding] GO:0048715 [negative regulation of oligodendrocyte differentiation] GO:0051287 [NAD binding] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] GO:0051726 [regulation of cell cycle] GO:0051775 [response to redox state] GO:0051781 [positive regulation of cell division] GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore] GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061433 [cellular response to caloric restriction] GO:0070403 [NAD+ binding] GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation] GO:0070932 [histone H3 deacetylation] GO:0070933 [histone H4 deacetylation] GO:0071219 [cellular response to molecule of bacterial origin] GO:0071456 [cellular response to hypoxia] GO:0071872 [cellular response to epinephrine stimulus] GO:0072686 [mitotic spindle] GO:0072687 [meiotic spindle] GO:0090042 [tubulin deacetylation] GO:0097386 [glial cell projection] GO:0097456 [terminal loop] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900195 [positive regulation of oocyte maturation] GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly] GO:1900425 [negative regulation of defense response to bacterium] GO:1901026 [ripoptosome assembly involved in necroptotic process] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]
Q8IXJ6 [Direct mapping] NAD-dependent protein deacetylase sirtuin-2 A0A024R0G8 [Target identity:100%; Query identity:100%] Sirtuin (Silent mating type information regulation 2 homolog) 2 (S. cerevisiae), isoform CRA_a
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000183 [chromatin silencing at rDNA] GO:0003682 [chromatin binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005677 [chromatin silencing complex] GO:0005694 [chromosome] GO:0005720 [nuclear heterochromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0006342 [chromatin silencing] GO:0006348 [chromatin silencing at telomere] GO:0006351 [transcription, DNA-templated] GO:0006471 [protein ADP-ribosylation] GO:0006476 [protein deacetylation] GO:0006914 [autophagy] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010507 [negative regulation of autophagy] GO:0010801 [negative regulation of peptidyl-threonine phosphorylation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016458 [gene silencing] GO:0016575 [histone deacetylation] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017136 [NAD-dependent histone deacetylase activity] GO:0021762 [substantia nigra development] GO:0022011 [myelination in peripheral nervous system] GO:0030426 [growth cone] GO:0030496 [midbody] GO:0031641 [regulation of myelination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0033010 [paranodal junction] GO:0033270 [paranode region of axon] GO:0033558 [protein deacetylase activity] GO:0034599 [cellular response to oxidative stress] GO:0034979 [NAD-dependent protein deacetylase activity] GO:0034983 [peptidyl-lysine deacetylation] GO:0035035 [histone acetyltransferase binding] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0042177 [negative regulation of protein catabolic process] GO:0042325 [regulation of phosphorylation] GO:0042826 [histone deacetylase binding] GO:0042903 [tubulin deacetylase activity] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043204 [perikaryon] GO:0043209 [myelin sheath] GO:0043219 [lateral loop] GO:0043220 [Schmidt-Lanterman incisure] GO:0043388 [positive regulation of DNA binding] GO:0043491 [protein kinase B signaling] GO:0044224 [juxtaparanode region of axon] GO:0044242 [cellular lipid catabolic process] GO:0045087 [innate immune response] GO:0045599 [negative regulation of fat cell differentiation] GO:0045836 [positive regulation of meiotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0051287 [NAD binding] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] GO:0051726 [regulation of cell cycle] GO:0051775 [response to redox state] GO:0051781 [positive regulation of cell division] GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore] GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061433 [cellular response to caloric restriction] GO:0070403 [NAD+ binding] GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation] GO:0070932 [histone H3 deacetylation] GO:0070933 [histone H4 deacetylation] GO:0071219 [cellular response to molecule of bacterial origin] GO:0071456 [cellular response to hypoxia] GO:0071872 [cellular response to epinephrine stimulus] GO:0072686 [mitotic spindle] GO:0072687 [meiotic spindle] GO:0090042 [tubulin deacetylation] GO:0097386 [glial cell projection] GO:1900119 [positive regulation of execution phase of apoptosis] GO:1900195 [positive regulation of oocyte maturation] GO:1900425 [negative regulation of defense response to bacterium] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]