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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SIRT2
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SIRT2

Gene description

Sirtuin 2

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in skeletal muscle.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. CAB004573 and HPA011165 may target different isoforms. Annotated protein expression is based on CAB004573.

Reliability score

Approved based on 2 antibodies.
HPA011165 , CAB004573
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SIRT2 (HGNC Symbol)

Synonyms

SIR2L

Description

Sirtuin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

38878555 - 38899862

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000068903 (version 83.38)

Entrez gene

22933

UniProt

Q8IXJ6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IXJ6

Antibodypedia

SIRT2 antibodies

PROTEIN BROWSER

SIRT2-001
SIRT2-002
SIRT2-005
SIRT2-006
SIRT2-007
SIRT2-008
SIRT2-016
SIRT2-201
SIRT2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRT2-001
ENSP00000249396
ENST00000249396
Q8IXJ6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000183 [chromatin silencing at rDNA]
GO:0003682 [chromatin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005677 [chromatin silencing complex]
GO:0005694 [chromosome]
GO:0005720 [nuclear heterochromatin]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006342 [chromatin silencing]
GO:0006348 [chromatin silencing at telomere]
GO:0006351 [transcription, DNA-templated]
GO:0006471 [protein ADP-ribosylation]
GO:0006476 [protein deacetylation]
GO:0006914 [autophagy]
GO:0007067 [mitotic nuclear division]
GO:0007096 [regulation of exit from mitosis]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016458 [gene silencing]
GO:0016575 [histone deacetylation]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0017136 [NAD-dependent histone deacetylase activity]
GO:0021762 [substantia nigra development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031641 [regulation of myelination]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033010 [paranodal junction]
GO:0033270 [paranode region of axon]
GO:0033558 [protein deacetylase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035035 [histone acetyltransferase binding]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035748 [myelin sheath abaxonal region]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042325 [regulation of phosphorylation]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0043219 [lateral loop]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043388 [positive regulation of DNA binding]
GO:0043491 [protein kinase B signaling]
GO:0044224 [juxtaparanode region of axon]
GO:0044242 [cellular lipid catabolic process]
GO:0045087 [innate immune response]
GO:0045598 [regulation of fat cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0051287 [NAD binding]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051781 [positive regulation of cell division]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061433 [cellular response to caloric restriction]
GO:0070403 [NAD+ binding]
GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071456 [cellular response to hypoxia]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:0090042 [tubulin deacetylation]
GO:0097386 [glial cell projection]
GO:0097456 [terminal loop]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900195 [positive regulation of oocyte maturation]
GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly]
GO:1900425 [negative regulation of defense response to bacterium]
GO:1901026 [ripoptosome assembly involved in necroptotic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]
Show all
389 aa
43.2 kDa
No 0
SIRT2-002
ENSP00000375931
ENST00000392081
Q8IXJ6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
A0A024R0G8 [Target identity:100%; Query identity:100%]
Sirtuin (Silent mating type information regulation 2 homolog) 2 (S. cerevisiae), isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000183 [chromatin silencing at rDNA]
GO:0003682 [chromatin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005677 [chromatin silencing complex]
GO:0005694 [chromosome]
GO:0005720 [nuclear heterochromatin]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006342 [chromatin silencing]
GO:0006348 [chromatin silencing at telomere]
GO:0006351 [transcription, DNA-templated]
GO:0006471 [protein ADP-ribosylation]
GO:0006476 [protein deacetylation]
GO:0006914 [autophagy]
GO:0007067 [mitotic nuclear division]
GO:0007096 [regulation of exit from mitosis]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016458 [gene silencing]
GO:0016575 [histone deacetylation]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0017136 [NAD-dependent histone deacetylase activity]
GO:0021762 [substantia nigra development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031641 [regulation of myelination]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033010 [paranodal junction]
GO:0033270 [paranode region of axon]
GO:0033558 [protein deacetylase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035035 [histone acetyltransferase binding]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042325 [regulation of phosphorylation]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0043219 [lateral loop]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043388 [positive regulation of DNA binding]
GO:0043491 [protein kinase B signaling]
GO:0044224 [juxtaparanode region of axon]
GO:0044242 [cellular lipid catabolic process]
GO:0045087 [innate immune response]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051287 [NAD binding]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051781 [positive regulation of cell division]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061433 [cellular response to caloric restriction]
GO:0070403 [NAD+ binding]
GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071456 [cellular response to hypoxia]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:0090042 [tubulin deacetylation]
GO:0097386 [glial cell projection]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900195 [positive regulation of oocyte maturation]
GO:1900425 [negative regulation of defense response to bacterium]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]
Show all
352 aa
39.5 kDa
No 0
SIRT2-005
ENSP00000385146
ENST00000407552
B5MCS1 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
169 aa
19.5 kDa
No 0
SIRT2-006
ENSP00000408023
ENST00000447739
C9JR33 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
73 aa
8.2 kDa
No 0
SIRT2-007
ENSP00000397022
ENST00000437828
C9J3U7 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
78 aa
8.8 kDa
No 0
SIRT2-008
ENSP00000404309
ENST00000414941
E7EWX6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
237 aa
27.1 kDa
No 0
SIRT2-016
ENSP00000401203
ENST00000381766
C9JZQ0 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
130 aa
15.1 kDa
No 0
SIRT2-201
ENSP00000351809
ENST00000358931
A0A0A0MRF5 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
234 aa
26.7 kDa
No 0
SIRT2-202
ENSP00000481932
ENST00000613542
A0A087WYM3 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0051287 [NAD binding]
GO:0070403 [NAD+ binding]
Show all
389 aa
43.3 kDa
No 0

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