Cell atlas - GNB5 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GNB5
Gene description	Guanine nucleotide binding protein (G protein), beta 5
Protein class	Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the centrosome & rods & rings.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Centrosome (approved), Rods & Rings (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044198
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the centrosome & rods & rings.

Main location

Nuclear speckles (approved)

Additional location

Centrosome (approved), Rods & Rings (approved)


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Antibody	Cell line	Location
HPA044198	A-431	Nuclear speckles
		Centrosome
		Rods & Rings
HPA044198	U-2 OS	Nuclear speckles
HPA044198	U-251 MG	Nucleoplasm
HPA044198	U-251 MG	Centrosome

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA044198	U-2 OS	Image	U-2 OS cells were treated with Ribavirin to induce the formation of Rods & Rings. Co-localization shows that GNB5 localizes to Rods & Rings as the staining overlaps with a marker for Rods & Rings.

GENE INFORMATION
Gene name	GNB5 (HGNC Symbol)
Synonyms	GB5
Description	Guanine nucleotide binding protein (G protein), beta 5 (HGNC Symbol)
Entrez gene summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	52115105 - 52191369
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069966 (version 83.38)
Entrez gene	10681
UniProt	O14775 (UniProt - Evidence at transcript level)
neXtProt	NX_O14775
Antibodypedia	GNB5 antibodies

PROTEIN BROWSER

GNB5-001	GNB5-002	GNB5-003	GNB5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNB5-001 ENSP00000261837 ENST00000261837	O14775 [Direct mapping] Guanine nucleotide-binding protein subunit beta-5 A0A024R5V3 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein (G protein), beta 5, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031682 [G-protein gamma-subunit binding] GO:0043209 [myelin sheath] GO:0051087 [chaperone binding] GO:1901386 [negative regulation of voltage-gated calcium channel activity] Show all	395 aa 43.6 kDa	No	0
GNB5-002 ENSP00000351635 ENST00000358784	O14775 [Direct mapping] Guanine nucleotide-binding protein subunit beta-5 A0A024R5R9 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein (G protein), beta 5, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031682 [G-protein gamma-subunit binding] GO:0051087 [chaperone binding] GO:1901386 [negative regulation of voltage-gated calcium channel activity] Show all	353 aa 38.8 kDa	No	0
GNB5-003 ENSP00000453176 ENST00000560116	Q96F32 [Direct mapping] GNB5 protein; Guanine nucleotide-binding protein subunit beta-5 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	126 aa 14.4 kDa	No	0
GNB5-004 ENSP00000379626 ENST00000396335	O14775 [Direct mapping] Guanine nucleotide-binding protein subunit beta-5 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031682 [G-protein gamma-subunit binding] GO:0051087 [chaperone binding] GO:1901386 [negative regulation of voltage-gated calcium channel activity] Show all	283 aa 31.2 kDa	No	0