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GNB5

GENERAL INFORMATION

Gene name

 GNB5

Gene description

 Guanine nucleotide binding protein (G protein), beta 5

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA041942 , CAB032353
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041942
CAB032353

GENE INFORMATION

Gene name

 GNB5 (HGNC Symbol)

Synonyms

 GB5

Description

 Guanine nucleotide binding protein (G protein), beta 5 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 52115105 - 52191369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069966 (version 83.38)

Entrez gene

 10681

UniProt

 O14775 (UniProt - Evidence at transcript level)

neXtProt

 NX_O14775

Antibodypedia

 GNB5 antibodies

PROTEIN BROWSER
GNB5-001
GNB5-002
GNB5-003
GNB5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNB5-001
ENSP00000261837
ENST00000261837
O14775 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-5
A0A024R5V3 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), beta 5, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031682 [G-protein gamma-subunit binding]
GO:0043209 [myelin sheath]
GO:0051087 [chaperone binding]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
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 395 aa
43.6 kDa 		No 0
GNB5-002
ENSP00000351635
ENST00000358784
O14775 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-5
A0A024R5R9 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), beta 5, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031682 [G-protein gamma-subunit binding]
GO:0051087 [chaperone binding]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
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 353 aa
38.8 kDa 		No 0
GNB5-003
ENSP00000453176
ENST00000560116
Q96F32 [Direct mapping]
GNB5 protein; Guanine nucleotide-binding protein subunit beta-5
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 126 aa
14.4 kDa 		No 0
GNB5-004
ENSP00000379626
ENST00000396335
O14775 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-5
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031682 [G-protein gamma-subunit binding]
GO:0051087 [chaperone binding]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
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 283 aa
31.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.