Expression of FSTL3 in cancer - Summary - The Human Protein Atlas

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FSTL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FSTL3
Gene description	Follistatin-like 3 (secreted glycoprotein)
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues, including placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA045378 , CAB024899
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable), ovarian cancer (unfavourable), colorectal cancer (unfavourable) and endometrial cancer (unfavourable).
Lung cancer p<0.001 Ovarian cancer p<0.001 Colorectal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045378	CAB024899

GENE INFORMATION
Gene name	FSTL3 (HGNC Symbol)
Synonyms	FLRG, FSRP
Description	Follistatin-like 3 (secreted glycoprotein) (HGNC Symbol)
Entrez gene summary	Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	676365 - 683399
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070404 (version 83.38)
Entrez gene	10272
UniProt	O95633 (UniProt - Evidence at protein level)
neXtProt	NX_O95633
Antibodypedia	FSTL3 antibodies

PROTEIN BROWSER

FSTL3-001	FSTL3-002	FSTL3-004	FSTL3-005	FSTL3-007	FSTL3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FSTL3-001 ENSP00000166139 ENST00000166139	O95633 [Direct mapping] Follistatin-related protein 3 A0A024R1Y8 [Target identity:100%; Query identity:100%] Follistatin-like 3 (Secreted glycoprotein), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0001822 [kidney development] GO:0001968 [fibronectin binding] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007283 [spermatogenesis] GO:0008584 [male gonad development] GO:0022409 [positive regulation of cell-cell adhesion] GO:0030141 [secretory granule] GO:0030324 [lung development] GO:0030325 [adrenal gland development] GO:0030514 [negative regulation of BMP signaling pathway] GO:0032926 [negative regulation of activin receptor signaling pathway] GO:0044306 [neuron projection terminus] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048185 [activin binding] GO:0071248 [cellular response to metal ion] GO:0090101 [negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway] Show all	263 aa 27.7 kDa	Yes	0
FSTL3-002 ENSP00000483064 ENST00000592947	K7EM71 [Direct mapping] Follistatin-related protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.2 kDa	No	0
FSTL3-004 ENSP00000484412 ENST00000605925	K7EM71 [Direct mapping] Follistatin-related protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.2 kDa	No	0
FSTL3-005 ENSP00000484376 ENST00000589185	A0A087X1Q2 [Direct mapping] Follistatin-related protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	84 aa 9.1 kDa	No	0
FSTL3-007 ENSP00000466383 ENST00000588773	K7EM71 [Direct mapping] Follistatin-related protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.2 kDa	No	0
FSTL3-008 ENSP00000477770 ENST00000591573	A0A087WTD3 [Direct mapping] Follistatin-related protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10 kDa	No	0

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The Human Protein Atlas

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