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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FSTL3
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FSTL3

Gene description

Follistatin-like 3 (secreted glycoprotein)

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Group enriched (placenta, testis)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in several tissues, including placenta.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA045378 , CAB024899
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, testis)

GENE INFORMATION

Gene name

FSTL3 (HGNC Symbol)

Synonyms

FLRG, FSRP

Description

Follistatin-like 3 (secreted glycoprotein) (HGNC Symbol)

Entrez gene summary

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

676365 - 683399

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070404 (version 83.38)

Entrez gene

10272

UniProt

O95633 (UniProt - Evidence at protein level)

neXtProt

NX_O95633

Antibodypedia

FSTL3 antibodies

PROTEIN BROWSER

FSTL3-001
FSTL3-002
FSTL3-004
FSTL3-005
FSTL3-007
FSTL3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FSTL3-001
ENSP00000166139
ENST00000166139
O95633 [Direct mapping]
Follistatin-related protein 3
A0A024R1Y8 [Target identity:100%; Query identity:100%]
Follistatin-like 3 (Secreted glycoprotein), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001822 [kidney development]
GO:0001968 [fibronectin binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0008584 [male gonad development]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030141 [secretory granule]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0044306 [neuron projection terminus]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048185 [activin binding]
GO:0071248 [cellular response to metal ion]
GO:0090101 [negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway]
Show all
263 aa
27.7 kDa
Yes 0
FSTL3-002
ENSP00000483064
ENST00000592947
K7EM71 [Direct mapping]
Follistatin-related protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
40 aa
4.2 kDa
No 0
FSTL3-004
ENSP00000484412
ENST00000605925
K7EM71 [Direct mapping]
Follistatin-related protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
40 aa
4.2 kDa
No 0
FSTL3-005
ENSP00000484376
ENST00000589185
A0A087X1Q2 [Direct mapping]
Follistatin-related protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
84 aa
9.1 kDa
No 0
FSTL3-007
ENSP00000466383
ENST00000588773
K7EM71 [Direct mapping]
Follistatin-related protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
40 aa
4.2 kDa
No 0
FSTL3-008
ENSP00000477770
ENST00000591573
A0A087WTD3 [Direct mapping]
Follistatin-related protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
92 aa
10 kDa
No 0

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