Expression of AFF4 in cancer - Summary - The Human Protein Atlas

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AFF4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AFF4
Gene description	AF4/FMR2 family, member 4
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA023690
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023690

GENE INFORMATION
Gene name	AFF4 (HGNC Symbol)
Synonyms	AF5Q31, MCEF
Description	AF4/FMR2 family, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	132875379 - 132963634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072364 (version 83.38)
Entrez gene	27125
UniProt	Q9UHB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHB7
Antibodypedia	AFF4 antibodies

PROTEIN BROWSER

AFF4-001	AFF4-004	AFF4-005	AFF4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFF4-001 ENSP00000265343 ENST00000265343	Q9UHB7 [Direct mapping] AF4/FMR2 family member 4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007286 [spermatid development] GO:0008023 [transcription elongation factor complex] GO:0035327 [transcriptionally active chromatin] Show all	1163 aa 127.5 kDa	No	0
AFF4-004 ENSP00000367858 ENST00000378595	Q9UHB7 [Direct mapping] AF4/FMR2 family member 4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008023 [transcription elongation factor complex] GO:0035327 [transcriptionally active chromatin] Show all	900 aa 98.2 kDa	No	0
AFF4-005 ENSP00000409069 ENST00000425658	H7C319 [Direct mapping] AF4/FMR2 family member 4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		171 aa 18 kDa	No	0
AFF4-009 ENSP00000395268 ENST00000421773	C9JCE0 [Direct mapping] AF4/FMR2 family member 4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.