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SCARB1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SCARB1

Gene description

Scavenger receptor class B, member 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (adrenal gland, placenta)
GTEx:Tissue enriched (adrenal gland)
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in a subset of tissues, including adrenal gland, Leydig cells, sinusoids in liver, vessels in placenta and salivary ducts.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA066285 , CAB070124
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SCARB1 (HGNC Symbol)

Synonyms

CD36L1, CLA-1, CLA1, SR-BI, SRB1

Description

Scavenger receptor class B, member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

124776856 - 124882668

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073060 (version 83.38)

Entrez gene

949

UniProt

Q8WTV0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WTV0

Antibodypedia

SCARB1 antibodies

PROTEIN BROWSER

SCARB1-001
SCARB1-004
SCARB1-006
SCARB1-007
SCARB1-009
SCARB1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCARB1-001
ENSP00000343795
ENST00000339570
Q8WTV0 [Direct mapping]
Scavenger receptor class B member 1
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001618 [virus receptor activity]
GO:0001786 [phosphatidylserine binding]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010886 [positive regulation of cholesterol storage]
GO:0010899 [regulation of phosphatidylcholine catabolic process]
GO:0015914 [phospholipid transport]
GO:0015920 [lipopolysaccharide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032497 [detection of lipopolysaccharide]
GO:0033344 [cholesterol efflux]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0035461 [vitamin transmembrane transport]
GO:0042060 [wound healing]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0043654 [recognition of apoptotic cell]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0044406 [adhesion of symbiont to host]
GO:0046718 [viral entry into host cell]
GO:0050764 [regulation of phagocytosis]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070506 [high-density lipoprotein particle receptor activity]
GO:0070508 [cholesterol import]
Show all
506 aa
56.2 kDa
No 1
SCARB1-004
ENSP00000261693
ENST00000261693
Q8WTV0 [Direct mapping]
Scavenger receptor class B member 1
A0A024RBS4 [Target identity:100%; Query identity:100%]
Scavenger receptor class B, member 1, isoform CRA_b
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001618 [virus receptor activity]
GO:0001786 [phosphatidylserine binding]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0001935 [endothelial cell proliferation]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006702 [androgen biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006910 [phagocytosis, recognition]
GO:0007155 [cell adhesion]
GO:0008035 [high-density lipoprotein particle binding]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010886 [positive regulation of cholesterol storage]
GO:0010899 [regulation of phosphatidylcholine catabolic process]
GO:0015914 [phospholipid transport]
GO:0015920 [lipopolysaccharide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030301 [cholesterol transport]
GO:0030666 [endocytic vesicle membrane]
GO:0031528 [microvillus membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032497 [detection of lipopolysaccharide]
GO:0033344 [cholesterol efflux]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0035461 [vitamin transmembrane transport]
GO:0042060 [wound healing]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043654 [recognition of apoptotic cell]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0044406 [adhesion of symbiont to host]
GO:0046718 [viral entry into host cell]
GO:0050764 [regulation of phagocytosis]
GO:0050892 [intestinal absorption]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070506 [high-density lipoprotein particle receptor activity]
GO:0070508 [cholesterol import]
Show all
509 aa
57 kDa
No 1
SCARB1-006
ENSP00000414979
ENST00000415380
Q8WTV0 [Direct mapping]
Scavenger receptor class B member 1
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001618 [virus receptor activity]
GO:0001786 [phosphatidylserine binding]
GO:0001875 [lipopolysaccharide receptor activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010886 [positive regulation of cholesterol storage]
GO:0010899 [regulation of phosphatidylcholine catabolic process]
GO:0015914 [phospholipid transport]
GO:0015920 [lipopolysaccharide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032497 [detection of lipopolysaccharide]
GO:0033344 [cholesterol efflux]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0035461 [vitamin transmembrane transport]
GO:0042060 [wound healing]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0043654 [recognition of apoptotic cell]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0044406 [adhesion of symbiont to host]
GO:0046718 [viral entry into host cell]
GO:0050764 [regulation of phagocytosis]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070506 [high-density lipoprotein particle receptor activity]
GO:0070508 [cholesterol import]
Show all
552 aa
60.9 kDa
No 1
SCARB1-007
ENSP00000442862
ENST00000546215
B7ZKQ9 [Direct mapping]
SCARB1 protein; Scavenger receptor class B member 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
481 aa
53.8 kDa
No 0
SCARB1-009
ENSP00000444851
ENST00000544327
F5H4X0 [Direct mapping]
Scavenger receptor class B member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
499 aa
55.4 kDa
No 1
SCARB1-012
ENSP00000443454
ENST00000545493
F5H5E8 [Direct mapping]
Scavenger receptor class B member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
146 aa
16.6 kDa
No 1

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