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ALPK1

GENERAL INFORMATION

Gene name

 ALPK1

Gene description

 Alpha-kinase 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at transcript level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA027435 , HPA027443
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALPK1 (HGNC Symbol)

Synonyms

 FLJ22670, KIAA1527, Lak

Description

 Alpha-kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 112285509 - 112442620

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000073331 (version 83.38)

Entrez gene

 80216

UniProt

 Q96QP1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96QP1

Antibodypedia

 ALPK1 antibodies

PROTEIN BROWSER
ALPK1-001
ALPK1-201
ALPK1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPK1-001
ENSP00000177648
ENST00000177648
Q96QP1 [Direct mapping]
Alpha-protein kinase 1
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Enzymes
   Kinases
   Atypical kinases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1244 aa
138.9 kDa 		No 0
ALPK1-201
ENSP00000398048
ENST00000458497
Q96QP1 [Direct mapping]
Alpha-protein kinase 1
Show all
Enzymes
   Kinases
   Atypical kinases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1244 aa
138.9 kDa 		No 0
ALPK1-202
ENSP00000426044
ENST00000504176
Q96QP1 [Direct mapping]
Alpha-protein kinase 1
Show all
Enzymes
   Kinases
   Atypical kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1166 aa
130 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.