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Strong nuclear immunoreactivity was observed in malignant cell.
GENE INFORMATION
Gene name
GLI2 (HGNC Symbol)
Synonyms
HPE9, THP1, THP2
Description
GLI family zinc finger 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0001822 [kidney development] GO:0002076 [osteoblast development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0007224 [smoothened signaling pathway] GO:0007389 [pattern specification process] GO:0007411 [axon guidance] GO:0007418 [ventral midline development] GO:0007442 [hindgut morphogenesis] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0009913 [epidermal cell differentiation] GO:0009954 [proximal/distal pattern formation] GO:0021508 [floor plate formation] GO:0021513 [spinal cord dorsal/ventral patterning] GO:0021517 [ventral spinal cord development] GO:0021696 [cerebellar cortex morphogenesis] GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification] GO:0021965 [spinal cord ventral commissure morphogenesis] GO:0021983 [pituitary gland development] GO:0030324 [lung development] GO:0030879 [mammary gland development] GO:0030902 [hindbrain development] GO:0033089 [positive regulation of T cell differentiation in thymus] GO:0035295 [tube development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043565 [sequence-specific DNA binding] GO:0045740 [positive regulation of DNA replication] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048566 [embryonic digestive tract development] GO:0048589 [developmental growth] GO:0048666 [neuron development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0097542 [ciliary tip] GO:0097546 [ciliary base] GO:0098586 [cellular response to virus]