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GLI2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GLI2

Gene description

GLI family zinc finger 2

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (ovary)
GTEx:Tissue enhanced (ovary)
FANTOM5:Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB008558
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
N/A
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)

GENE INFORMATION

Gene name

GLI2 (HGNC Symbol)

Synonyms

HPE9, THP1, THP2

Description

GLI family zinc finger 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

120735623 - 120992653

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074047 (version 83.38)

Entrez gene

2736

UniProt

P10070 (UniProt - Evidence at protein level)

neXtProt

NX_P10070

Antibodypedia

GLI2 antibodies

PROTEIN BROWSER

GLI2-007
GLI2-009
GLI2-012
GLI2-201
GLI2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLI2-007
ENSP00000398992
ENST00000418323
Q1PSW9 [Direct mapping]
GLI2 transcription factor; Zinc finger protein GLI2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
82 aa
8.5 kDa
No 0
GLI2-009
ENSP00000390436
ENST00000452319
P10070 [Direct mapping]
Zinc finger protein GLI2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0002009 [morphogenesis of an epithelium]
GO:0002062 [chondrocyte differentiation]
GO:0002076 [osteoblast development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007224 [smoothened signaling pathway]
GO:0007389 [pattern specification process]
GO:0007411 [axon guidance]
GO:0007418 [ventral midline development]
GO:0007442 [hindgut morphogenesis]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009612 [response to mechanical stimulus]
GO:0009913 [epidermal cell differentiation]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0021508 [floor plate formation]
GO:0021513 [spinal cord dorsal/ventral patterning]
GO:0021517 [ventral spinal cord development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification]
GO:0021776 [smoothened signaling pathway involved in spinal cord motor neuron cell fate specification]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0021915 [neural tube development]
GO:0021938 [smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation]
GO:0021965 [spinal cord ventral commissure morphogenesis]
GO:0021983 [pituitary gland development]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0030879 [mammary gland development]
GO:0030902 [hindbrain development]
GO:0031512 [motile primary cilium]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035295 [tube development]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048566 [embryonic digestive tract development]
GO:0048589 [developmental growth]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048666 [neuron development]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048856 [anatomical structure development]
GO:0060032 [notochord regression]
GO:0060322 [head development]
GO:0060513 [prostatic bud formation]
GO:0060603 [mammary gland duct morphogenesis]
GO:0060831 [smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
GO:0071407 [cellular response to organic cyclic compound]
GO:0072372 [primary cilium]
GO:0090103 [cochlea morphogenesis]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
GO:0098586 [cellular response to virus]
Show all
1586 aa
167.8 kDa
No 0
GLI2-012
ENSP00000441454
ENST00000360874
H0YG23 [Direct mapping]
Zinc finger protein GLI2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
176 aa
18.4 kDa
No 0
GLI2-201
ENSP00000312694
ENST00000314490
A0A0A0MR29 [Direct mapping]
Zinc finger protein GLI2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
522 aa
57.2 kDa
No 0
GLI2-202
ENSP00000354586
ENST00000361492
P10070 [Direct mapping]
Zinc finger protein GLI2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001822 [kidney development]
GO:0002076 [osteoblast development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0007224 [smoothened signaling pathway]
GO:0007389 [pattern specification process]
GO:0007411 [axon guidance]
GO:0007418 [ventral midline development]
GO:0007442 [hindgut morphogenesis]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0009913 [epidermal cell differentiation]
GO:0009954 [proximal/distal pattern formation]
GO:0021508 [floor plate formation]
GO:0021513 [spinal cord dorsal/ventral patterning]
GO:0021517 [ventral spinal cord development]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021775 [smoothened signaling pathway involved in ventral spinal cord interneuron specification]
GO:0021965 [spinal cord ventral commissure morphogenesis]
GO:0021983 [pituitary gland development]
GO:0030324 [lung development]
GO:0030879 [mammary gland development]
GO:0030902 [hindbrain development]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035295 [tube development]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043565 [sequence-specific DNA binding]
GO:0045740 [positive regulation of DNA replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048566 [embryonic digestive tract development]
GO:0048589 [developmental growth]
GO:0048666 [neuron development]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
GO:0098586 [cellular response to virus]
Show all
1586 aa
167.8 kDa
No 0

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The Human Protein Atlas project is funded
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