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CLNS1A

GENERAL INFORMATION

Gene name

 CLNS1A

Gene description

 Chloride channel, nucleotide-sensitive, 1A

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA031707 , HPA031708 , HPA032045 , CAB017840
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Rectum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CLNS1A (HGNC Symbol)

Synonyms

 CLCI, ICln

Description

 Chloride channel, nucleotide-sensitive, 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 11

Cytoband

 q14.1

Chromosome location (bp)

 77514936 - 77637805

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074201 (version 83.38)

Entrez gene

 1207

UniProt

 P54105 (UniProt - Evidence at protein level)

neXtProt

 NX_P54105

Antibodypedia

 CLNS1A antibodies

PROTEIN BROWSER
CLNS1A-001
CLNS1A-002
CLNS1A-003
CLNS1A-006
CLNS1A-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLNS1A-001
ENSP00000433919
ENST00000525428
P54105 [Direct mapping]
Methylosome subunit pICln
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0010467 [gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046982 [protein heterodimerization activity]
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 237 aa
26.2 kDa 		No 0
CLNS1A-002
ENSP00000263309
ENST00000263309
J3KN38 [Direct mapping]
Methylosome subunit pICln
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
Show all
 203 aa
22.3 kDa 		No 0
CLNS1A-003
ENSP00000434963
ENST00000532069
E9PMI6 [Direct mapping]
Methylosome subunit pICln
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
Show all
 167 aa
18.3 kDa 		No 0
CLNS1A-006
ENSP00000434311
ENST00000528364
P54105 [Direct mapping]
Methylosome subunit pICln
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0010467 [gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046982 [protein heterodimerization activity]
Show all
 237 aa
26.2 kDa 		No 0
CLNS1A-007
ENSP00000433741
ENST00000525064
E9PJF4 [Direct mapping]
Methylosome subunit pICln
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006884 [cell volume homeostasis]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
Show all
 179 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.