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SNCB

GENERAL INFORMATION

Gene name

 SNCB

Gene description

 Synuclein, beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in neuropil and cells in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035876 , CAB002681
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA035876
CAB002681

GENE INFORMATION

Gene name

 SNCB

Synonyms

Description

 Synuclein, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 176620084 - 176630556

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074317 (version 83.38)

Entrez gene

 6620

UniProt

 Q16143 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16143

Antibodypedia

 SNCB antibodies

PROTEIN BROWSER
SNCB-001
SNCB-002
SNCB-003
SNCB-005
SNCB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNCB-001
ENSP00000308057
ENST00000310112
Q16143 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0007268 [synaptic transmission]
GO:0016234 [inclusion body]
GO:0030426 [growth cone]
GO:0042417 [dopamine metabolic process]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043086 [negative regulation of catalytic activity]
GO:0043195 [terminal bouton]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0048487 [beta-tubulin binding]
GO:0050808 [synapse organization]
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 134 aa
14.3 kDa 		No 0
SNCB-002
ENSP00000377296
ENST00000393693
Q16143 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
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 134 aa
14.3 kDa 		No 0
SNCB-003
ENSP00000422223
ENST00000506696
Q16143 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
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 134 aa
14.3 kDa 		No 0
SNCB-005
ENSP00000424073
ENST00000510387
Q16143 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
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 134 aa
14.3 kDa 		No 0
SNCB-201
ENSP00000479489
ENST00000614675
G4Y816 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
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 120 aa
12.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.