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SNCB

GENERAL INFORMATION

Gene name

 SNCB

Gene description

 Synuclein, beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in neuropil and cells in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035876 , CAB002681
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 SNCB

Synonyms

Description

 Synuclein, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 176620084 - 176630556

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074317 (version 83.38)

Entrez gene

 6620

UniProt

 Q16143 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16143

Antibodypedia

 SNCB antibodies

PROTEIN BROWSER
SNCB-001
SNCB-002
SNCB-003
SNCB-005
SNCB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNCB-001
ENSP00000308057
ENST00000310112
Q16143 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0007268 [synaptic transmission]
GO:0016234 [inclusion body]
GO:0030426 [growth cone]
GO:0042417 [dopamine metabolic process]
GO:0043014 [alpha-tubulin binding]
GO:0043025 [neuronal cell body]
GO:0043086 [negative regulation of catalytic activity]
GO:0043195 [terminal bouton]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0048487 [beta-tubulin binding]
GO:0050808 [synapse organization]
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 134 aa
14.3 kDa 		No 0
SNCB-002
ENSP00000377296
ENST00000393693
Q16143 [Direct mapping]
Beta-synuclein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
Show all
 134 aa
14.3 kDa 		No 0
SNCB-003
ENSP00000422223
ENST00000506696
Q16143 [Direct mapping]
Beta-synuclein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
Show all
 134 aa
14.3 kDa 		No 0
SNCB-005
ENSP00000424073
ENST00000510387
Q16143 [Direct mapping]
Beta-synuclein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0016234 [inclusion body]
GO:0043086 [negative regulation of catalytic activity]
Show all
 134 aa
14.3 kDa 		No 0
SNCB-201
ENSP00000479489
ENST00000614675
G4Y816 [Direct mapping]
Beta-synuclein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
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 120 aa
12.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.