Expression of CA12 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CA12
Gene description	Carbonic anhydrase XII
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549, RT4, T-47d, U-138 MG, U-87 MG)
HPA (normal tissue):	Tissue enhanced (kidney, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several cell types, most abundant in intestinal tract and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA008773 , CAB025181 , CAB062549 , CAB068179
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008773	CAB025181	CAB062549	CAB068179

GENE INFORMATION
Gene name	CA12 (HGNC Symbol)
Synonyms	HsT18816
Description	Carbonic anhydrase XII (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	63321378 - 63382161
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074410 (version 83.38)
Entrez gene	771
UniProt	O43570 (UniProt - Evidence at protein level)
neXtProt	NX_O43570
Antibodypedia	CA12 antibodies

PROTEIN BROWSER

CA12-001	CA12-002	CA12-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA12-001 ENSP00000178638 ENST00000178638	O43570 [Direct mapping] Carbonic anhydrase 12 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055064 [chloride ion homeostasis] Show all	354 aa 39.5 kDa	Yes	1
CA12-002 ENSP00000343088 ENST00000344366	O43570 [Direct mapping] Carbonic anhydrase 12 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005886 [plasma membrane] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055064 [chloride ion homeostasis] Show all	343 aa 38.4 kDa	Yes	1
CA12-003 ENSP00000403028 ENST00000422263	B3KUB4 [Direct mapping] Carbonic anhydrase 12; Carbonic anhydrase XII, isoform CRA_d; cDNA FLJ39526 fis, clone PUAEN2003018, highly similar to CARBONIC ANHYDRASE XII (EC 4.2.1.1) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	283 aa 31.9 kDa	Yes	1