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CA12

GENERAL INFORMATION

Gene name

 CA12

Gene description

 Carbonic anhydrase XII

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney, skin)
GTEx:Tissue enhanced (kidney)
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several cell types, most abundant in intestinal tract and renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA008773 , CAB025181 , CAB062549 , CAB068179
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 CA12 (HGNC Symbol)

Synonyms

 HsT18816

Description

 Carbonic anhydrase XII (HGNC Symbol)

Entrez gene summary

 Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 63321378 - 63382161

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074410 (version 83.38)

Entrez gene

 771

UniProt

 O43570 (UniProt - Evidence at protein level)

neXtProt

 NX_O43570

Antibodypedia

 CA12 antibodies

PROTEIN BROWSER
CA12-001
CA12-002
CA12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CA12-001
ENSP00000178638
ENST00000178638
O43570 [Direct mapping]
Carbonic anhydrase 12
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Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005886 [plasma membrane]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055064 [chloride ion homeostasis]
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 354 aa
39.5 kDa 		Yes 1
CA12-002
ENSP00000343088
ENST00000344366
O43570 [Direct mapping]
Carbonic anhydrase 12
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005886 [plasma membrane]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055064 [chloride ion homeostasis]
Show all
 343 aa
38.4 kDa 		Yes 1
CA12-003
ENSP00000403028
ENST00000422263
B3KUB4 [Direct mapping]
Carbonic anhydrase 12; Carbonic anhydrase XII, isoform CRA_d; cDNA FLJ39526 fis, clone PUAEN2003018, highly similar to CARBONIC ANHYDRASE XII (EC 4.2.1.1)
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
 283 aa
31.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.