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Colorectal, ovarian and endometrial cancers as well as a few cases of lymphomas and liver cancers showed weak to moderate cytoplasmic immunoreactivity with additional nuclear or membranous staining in some cases. Remaining cancers were generally negative.
Most cancers displayed weak to moderate cytoplasmic positivity with additional membranous staining in several cases. Several carcinoids, renal and colorectal cancers along with a few breast, stomach, liver and pancreatic cancers were strongly stained. Many gliomas and lymphomas were negative.
GENE INFORMATION
Gene name
EDN1 (HGNC Symbol)
Synonyms
ET1
Description
Endothelin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]