Expression of SCGN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SCGN
Gene description	Secretagogin, EF-hand calcium binding protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (pancreatic cancer)
HPA (cell line):	Cell line enriched (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (rectum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic and nuclear expression in islets of Langerhans, enteroendocrine cells, and cells in the molecular cell layer of cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA006641 , CAB004005 , CAB062563 , CAB068232
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006641	CAB004005	CAB062563	CAB068232

GENE INFORMATION
Gene name	SCGN (HGNC Symbol)
Synonyms	CALBL, DJ501N12.8, SECRET, SEGN
Description	Secretagogin, EF-hand calcium binding protein (HGNC Symbol)
Entrez gene summary	The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	25652201 - 25701783
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079689 (version 83.38)
Entrez gene	10590
UniProt	O76038 (UniProt - Evidence at transcript level)
neXtProt	NX_O76038
Antibodypedia	SCGN antibodies

PROTEIN BROWSER

SCGN-001	SCGN-201	SCGN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCGN-001 ENSP00000367197 ENST00000377961	O76038 [Direct mapping] Secretagogin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0030658 [transport vesicle membrane] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0051480 [cytosolic calcium ion homeostasis] Show all	276 aa 32 kDa	No	0
SCGN-201 ENSP00000333933 ENST00000334979	Q96P10 [Direct mapping] Secretagogin; Secretagogin, EF-hand calcium binding protein, isoform CRA_b; Setagin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.6 kDa	No	0
SCGN-202 ENSP00000484392 ENST00000612225	Q96P10 [Direct mapping] Secretagogin; Secretagogin, EF-hand calcium binding protein, isoform CRA_b; Setagin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.6 kDa	No	0