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SCGN

GENERAL INFORMATION

Gene name

 SCGN

Gene description

 Secretagogin, EF-hand calcium binding protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum, stomach)
GTEx:Tissue enhanced (cerebellum, hypothalamus, pituitary gland)
FANTOM5:Tissue enhanced (cerebellum, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic and nuclear expression in islets of Langerhans, enteroendocrine cells, and cells in the molecular cell layer of cerebellum.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA006641 , CAB004005 , CAB062563 , CAB068232
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, pituitary gland)

GENE INFORMATION

Gene name

 SCGN (HGNC Symbol)

Synonyms

 CALBL, DJ501N12.8, SECRET, SEGN

Description

 Secretagogin, EF-hand calcium binding protein (HGNC Symbol)

Entrez gene summary

 The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 25652201 - 25701783

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079689 (version 83.38)

Entrez gene

 10590

UniProt

 O76038 (UniProt - Evidence at transcript level)

neXtProt

 NX_O76038

Antibodypedia

 SCGN antibodies

PROTEIN BROWSER
SCGN-001
SCGN-201
SCGN-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCGN-001
ENSP00000367197
ENST00000377961
O76038 [Direct mapping]
Secretagogin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008150 [biological_process]
GO:0030658 [transport vesicle membrane]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0051480 [cytosolic calcium ion homeostasis]
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 276 aa
32 kDa 		No 0
SCGN-201
ENSP00000333933
ENST00000334979
Q96P10 [Direct mapping]
Secretagogin; Secretagogin, EF-hand calcium binding protein, isoform CRA_b; Setagin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 49 aa
5.6 kDa 		No 0
SCGN-202
ENSP00000484392
ENST00000612225
Q96P10 [Direct mapping]
Secretagogin; Secretagogin, EF-hand calcium binding protein, isoform CRA_b; Setagin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.