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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DCT

Gene description

Dopachrome tautomerase

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in melanocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA010743 , HPA010800 , CAB017634
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA010743
HPA010800
CAB017634

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant melanomas showed distinct cytoplasmic immunoreactivity. Remaining malignant cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant melanomas showed distinct cytoplasmic staining. Malignant cells in general were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant melanomas exhibited strong cytoplasmic staining. Malignant cells in general were negative.

GENE INFORMATION

Gene name

DCT (HGNC Symbol)

Synonyms

TYRP2

Description

Dopachrome tautomerase (HGNC Symbol)

Entrez gene summary

Chromosome

13

Cytoband

q32.1

Chromosome location (bp)

94436808 - 94479682

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080166 (version 83.38)

Entrez gene

1638

UniProt

P40126 (UniProt - Evidence at protein level)

neXtProt

NX_P40126

Antibodypedia

DCT antibodies

PROTEIN BROWSER

DCT-001
DCT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCT-001
ENSP00000366227
ENST00000377028
P40126 [Direct mapping]
L-dopachrome tautomerase
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Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004167 [dopachrome isomerase activity]
GO:0005507 [copper ion binding]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
519 aa
59.1 kDa
Yes 1
DCT-201
ENSP00000392762
ENST00000446125
P40126 [Direct mapping]
L-dopachrome tautomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004167 [dopachrome isomerase activity]
GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0021847 [ventricular zone neuroblast division]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0048066 [developmental pigmentation]
GO:0048468 [cell development]
GO:0055114 [oxidation-reduction process]
Show all
552 aa
62.9 kDa
Yes 1

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