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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PTPRC
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PTPRC

Gene description

Protein tyrosine phosphatase, receptor type, C

Protein class

Cancer-related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Daudi, HEL, HL-60, MOLT-4, U-698)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in lymphoid tissue and immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA000440 , CAB000052 , CAB002800 , CAB056154 , CAB068221
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

HPA000440
CAB000052
CAB002800
CAB056154
CAB068221

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Non-Hodgkin's lymphomas showed moderate to strong cytoplasmic immunoreactivity. Other cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant lymphoma showed strong cytoplasmic positivity. All other tumors were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
Melanoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells were generally negative. Strong membranous and cytoplasmic immunoreactivity was observed in malignant lymphomas.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several non-Hodgkin's lymphomas exhibited moderate to strong cytoplasmic positivity. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic positivity was observed in non-Hodgkin's lymphomas. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

PTPRC (HGNC Symbol)

Synonyms

CD45, GP180, LCA, T200

Description

Protein tyrosine phosphatase, receptor type, C (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Chromosome

1

Cytoband

Chromosome location (bp)

198638671 - 198757283

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081237 (version 83.38)

Entrez gene

5788

UniProt

neXtProt

Antibodypedia

PTPRC antibodies

PROTEIN BROWSER

PTPRC-001
PTPRC-002
PTPRC-003
PTPRC-004
PTPRC-005
PTPRC-006
PTPRC-009
PTPRC-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRC-001
ENSP00000411355
ENST00000442510
A0A0A0MT22 [Direct mapping]
Protein tyrosine phosphatase, receptor type, C, isoform CRA_d; Receptor-type tyrosine-protein phosphatase C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002711 [positive regulation of T cell mediated immunity]
GO:0002923 [regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010332 [response to gamma radiation]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030183 [B cell differentiation]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042098 [T cell proliferation]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045059 [positive thymic T cell selection]
GO:0045060 [negative thymic T cell selection]
GO:0045577 [regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048304 [positive regulation of isotype switching to IgG isotypes]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050855 [regulation of B cell receptor signaling pathway]
GO:0051607 [defense response to virus]
GO:0071944 [cell periphery]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
1306 aa
147.5 kDa
Yes 1
PTPRC-002
ENSP00000306782
ENST00000348564
X6R433 [Direct mapping]
Protein-tyrosine-phosphatase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0006470 [protein dephosphorylation]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050852 [T cell receptor signaling pathway]
Show all
1145 aa
131.1 kDa
Yes 1
PTPRC-003
ENSP00000393360
ENST00000418674
M9MML3 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
118 aa
12.6 kDa
Yes 0
PTPRC-004
ENSP00000356334
ENST00000367364
M9MMK8 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
36 aa
4 kDa
Yes 0
PTPRC-005
ENSP00000356337
ENST00000367367
M3ZCP1 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0006470 [protein dephosphorylation]
GO:0016021 [integral component of membrane]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050852 [T cell receptor signaling pathway]
Show all
735 aa
83 kDa
Yes 1
PTPRC-006
ENSP00000433536
ENST00000530727
E9PKH0 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0006470 [protein dephosphorylation]
GO:0016021 [integral component of membrane]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050852 [T cell receptor signaling pathway]
Show all
600 aa
67.9 kDa
Yes 1
PTPRC-009
ENSP00000405494
ENST00000413409
M9MML4 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
87 aa
9.7 kDa
Yes 0
PTPRC-011
ENSP00000356349
ENST00000367379
M9MMK9 [Direct mapping]
Receptor-type tyrosine-protein phosphatase C
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050852 [T cell receptor signaling pathway]
Show all
148 aa
16.1 kDa
Yes 0

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