Tissue expression of PTPRC - Summary - The Human Protein Atlas

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PTPRC

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PTPRC
Gene description	Protein tyrosine phosphatase, receptor type, C
Protein class	Cancer-related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Group enriched (lung, small intestine, spleen)
FANTOM5:	Group enriched (appendix, lung, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in lymphoid tissue and immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 5 antibodies. HPA000440 , CAB000052 , CAB002800 , CAB056154 , CAB068221
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, lung, lymph node, spleen, tonsil)

GENE INFORMATION
Gene name	PTPRC (HGNC Symbol)
Synonyms	CD45, GP180, LCA, T200
Description	Protein tyrosine phosphatase, receptor type, C (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Chromosome	1
Cytoband
Chromosome location (bp)	198638671 - 198757283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081237 (version 83.38)
Entrez gene	5788
UniProt
neXtProt
Antibodypedia	PTPRC antibodies

PROTEIN BROWSER

PTPRC-001	PTPRC-002	PTPRC-003	PTPRC-004	PTPRC-005	PTPRC-006	PTPRC-009	PTPRC-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRC-001 ENSP00000411355 ENST00000442510	A0A0A0MT22 [Direct mapping] Protein tyrosine phosphatase, receptor type, C, isoform CRA_d; Receptor-type tyrosine-protein phosphatase C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002711 [positive regulation of T cell mediated immunity] GO:0002923 [regulation of humoral immune response mediated by circulating immunoglobulin] GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0007159 [leukocyte cell-cell adhesion] GO:0008201 [heparin binding] GO:0009986 [cell surface] GO:0010332 [response to gamma radiation] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030183 [B cell differentiation] GO:0031953 [negative regulation of protein autophosphorylation] GO:0034113 [heterotypic cell-cell adhesion] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042098 [T cell proliferation] GO:0043395 [heparan sulfate proteoglycan binding] GO:0043410 [positive regulation of MAPK cascade] GO:0045059 [positive thymic T cell selection] GO:0045060 [negative thymic T cell selection] GO:0045577 [regulation of B cell differentiation] GO:0045582 [positive regulation of T cell differentiation] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0046641 [positive regulation of alpha-beta T cell proliferation] GO:0048304 [positive regulation of isotype switching to IgG isotypes] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0051607 [defense response to virus] GO:0071944 [cell periphery] GO:2001236 [regulation of extrinsic apoptotic signaling pathway] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	1306 aa 147.5 kDa	Yes	1
PTPRC-002 ENSP00000306782 ENST00000348564	X6R433 [Direct mapping] Protein-tyrosine-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050852 [T cell receptor signaling pathway] Show all	1145 aa 131.1 kDa	Yes	1
PTPRC-003 ENSP00000393360 ENST00000418674	M9MML3 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		118 aa 12.6 kDa	Yes	0
PTPRC-004 ENSP00000356334 ENST00000367364	M9MMK8 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4 kDa	Yes	0
PTPRC-005 ENSP00000356337 ENST00000367367	M3ZCP1 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050852 [T cell receptor signaling pathway] Show all	735 aa 83 kDa	Yes	1
PTPRC-006 ENSP00000433536 ENST00000530727	E9PKH0 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050852 [T cell receptor signaling pathway] Show all	600 aa 67.9 kDa	Yes	1
PTPRC-009 ENSP00000405494 ENST00000413409	M9MML4 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		87 aa 9.7 kDa	Yes	0
PTPRC-011 ENSP00000356349 ENST00000367379	M9MMK9 [Direct mapping] Receptor-type tyrosine-protein phosphatase C Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0050852 [T cell receptor signaling pathway] Show all	148 aa 16.1 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.