Cell atlas - GEMIN5 - The Human Protein Atlas

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GEMIN5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GEMIN5
Gene description	Gem (nuclear organelle) associated protein 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Nuclear bodies (supported)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA037392 , HPA037393
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ASSAYS

RNA expression

Human cells

GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nuclear bodies.

Main location

Cytosol (validated)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037392	U-251 MG	No staining
HPA037393	A-431	Nuclear bodies
HPA037393	A-431	Cytosol
HPA037393	U-2 OS	Nuclear bodies
HPA037393	U-2 OS	Cytosol
HPA037393	U-251 MG	Nuclear bodies
HPA037393	U-251 MG	Cytosol

GFP

Antibody	HPA037392
Validation	C-terminal tag BAC cell line: 4594 Validated: Antibody staining overlaps with GFP tagged protein

Antibody	HPA037393
Validation	C-terminal tag BAC cell line: 4594 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
HPA037392	HeLa	4594	C-terminal	Cytosol	Cytosol
HPA037392	HeLa	Normal	-	No staining	-
HPA037393	HeLa	4594	C-terminal	Cytosol	Cytosol
HPA037393	HeLa	Normal	-	Nucleoplasm, Cytosol	-

GENE INFORMATION
Gene name	GEMIN5
Synonyms
Description	Gem (nuclear organelle) associated protein 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	5
Cytoband	q33.2
Chromosome location (bp)	154887416 - 154938209
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082516 (version 83.38)
Entrez gene	25929
UniProt	Q8TEQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TEQ6
Antibodypedia	GEMIN5 antibodies

PROTEIN BROWSER

GEMIN5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GEMIN5-001 ENSP00000285873 ENST00000285873	Q8TEQ6 [Direct mapping] Gem-associated protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000387 [spliceosomal snRNP assembly] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016604 [nuclear body] GO:0017069 [snRNA binding] GO:0032797 [SMN complex] GO:0034660 [ncRNA metabolic process] GO:0034719 [SMN-Sm protein complex] GO:0044822 [poly(A) RNA binding] GO:0097504 [Gemini of coiled bodies] Show all	1508 aa 168.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.